UniProt Accession

 MIP_BOVIN; P06624 

Genbank Protein ID

 K02818 

Genbank Nucleotide ID

 AAA30622.1 

Protein Name

 Lens fiber major intrinsic protein 

Protein Synonyms/Alias

 Aquaporin-0; MIP26; MP26 

Gene Name

 MIP 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
238	SERLSILKGSRPSES	glycation	[1]
259	TGEPVELKTQAL***	glycation	[1]

Reference

 [1] Mass spectroscopic identification of in vitro glycated sites of MIP.
 Swamy-Mruthinti S, Schey KL.
 Curr Eye Res. 1997 Sep;16(9):936-41. [PMID: 9288456] 

Functional Description

 Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core. 

Sequence Annotation

 MOTIF 68 70 NPA 1.
 MOTIF 184 186 NPA 2.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 243 243 Phosphoserine; by PKA.
 MOD_RES 245 245 Phosphoserine.
 MOD_RES 246 246 Deamidated asparagine.  

Keyword

 3D-structure; Cell junction; Cell membrane; Complete proteome; Direct protein sequencing; Eye lens protein; Gap junction; Membrane; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 263 AA 

Protein Sequence

Gene Ontology

 GO:0005921; C:gap junction; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0005212; F:structural constituent of eye lens; IEA:UniProtKB-KW.
 GO:0015250; F:water channel activity; IEA:Compara.
 GO:0002088; P:lens development in camera-type eye; IEA:Compara.
 GO:0007601; P:visual perception; IEA:Compara. 

Interpro

 IPR023271; Aquaporin-like.
 IPR000425; MIP.
 IPR022357; MIP_CS. 

Pfam

 PF00230; MIP 

SMART

  

PROSITE

 PS00221; MIP 

PRINTS

 PR00783; MINTRINSICP.