UniProt Accession

 ACSM2_RAT; O70490; Q6AZ63 

Genbank Protein ID

 AF062389; BC078721 

Genbank Nucleotide ID

 AAD05209.1; AAH78721.1 

Protein Name

 Acyl-coenzyme A synthetase ACSM2, mitochondrial 

Protein Synonyms/Alias

 Acyl-CoA synthetase medium-chain family member 2; Butyrate--CoA ligase 2; Butyryl-coenzyme A synthetase 2; Kidney-specific protein KS; Middle-chain acyl-CoA synthetase 2 

Gene Name

 Acsm2 

Gene Synonyms/Alias

 Ks 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
59	DHWASLEKAGKRSPG	acetylation	[1]
141	MPGTTQMKSTDILYR	acetylation	[1]
180	DCSFLKIKLLVSEKN	acetylation	[1]
186	IKLLVSEKNREGWLN	acetylation	[1]
195	REGWLNFKALLKDAS	acetylation	[1]
406	GNVLPPGKEGDMALR	acetylation	[1]
415	GDMALRVKPIRPIGM	acetylation	[1]
450	LLGDRGIKDTEGYFH	acetylation	[1]
532	KVLQEHVKSVTAPYK	acetylation	[1]
557	LPKTITGKIERAKLR	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) (By similarity). 

Sequence Annotation

 NP_BIND 221 229 ATP (By similarity).
 NP_BIND 359 364 ATP (By similarity).
 REGION 469 471 Coenzyme A binding (By similarity).
 REGION 540 542 Coenzyme A binding (By similarity).
 BINDING 139 139 Coenzyme A (By similarity).
 BINDING 364 364 Substrate (By similarity).
 BINDING 446 446 ATP (By similarity).
 BINDING 461 461 ATP (By similarity).
 BINDING 472 472 Substrate (By similarity).
 BINDING 501 501 Coenzyme A (By similarity).
 BINDING 532 532 Coenzyme A (By similarity).
 BINDING 557 557 ATP (By similarity).  

Keyword

 ATP-binding; Complete proteome; Fatty acid metabolism; Ligase; Lipid metabolism; Magnesium; Metal-binding; Mitochondrion; Nucleotide-binding; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 572 AA 

Protein Sequence

Gene Ontology

 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0047760; F:butyrate-CoA ligase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR020845; AMP-binding_CS.
 IPR000873; AMP-dep_Synth/Lig.
 IPR025110; DUF4009. 

Pfam

 PF00501; AMP-binding
 PF13193; DUF4009 

SMART

  

PROSITE

 PS00455; AMP_BINDING 

PRINTS