| Tag | Content |
|---|
| CPLM ID | CPLM-018121 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Nucleoporin NDC1 |
Protein Synonyms/Alias | Transmembrane protein 48 |
Gene Name | Ndc1 |
Gene Synonyms/Alias | Tmem48 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 429 | PSVPPLVKTSLFSPK | ubiquitination | [1] | | 436 | KTSLFSPKLSTPNVS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Component of the nuclear pore complex (NPC), which plays a key role in de novo assembly and insertion of NPC in the nuclear envelope. Required for NPC and nuclear envelope assembly, possibly by forming a link between the nuclear envelope membrane and soluble nucleoporins, thereby anchoring the NPC in the membrane (By similarity). |
Sequence Annotation | MOD_RES 407 407 Phosphoserine (By similarity).
MOD_RES 415 415 Phosphothreonine (By similarity).
MOD_RES 438 438 Phosphoserine (By similarity).
MOD_RES 439 439 Phosphothreonine (By similarity).
MOD_RES 444 444 Phosphoserine (By similarity).
MOD_RES 448 448 Phosphothreonine (By similarity).
MOD_RES 470 470 Phosphoserine (By similarity).
MOD_RES 473 473 Phosphoserine (By similarity). |
Keyword | Complete proteome; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 673 AA |
Protein Sequence | MATAASGPCA GGSPRDILWR VLGWRIVTSI VWSVVLLPVC ITAFIVLSSI NLFHPIQWLS 60
DSCNDFYSSQ VIFHLLLLAV VIIIISIFNV EFYTVVPSIS GSRLALIARI LHPQQLTHSF 120
IHAAMGMAVA WCAAIMTKGQ YSSLVVPCTG TESLDSPAAQ TCLNEYHLFF LLSGAFMGYS 180
YSLLYFINNM NYLPFPIIQQ YKFLRFRRSL LLLVKHSCVE SLFMVRNFCI VYYFFGHIPK 240
AWISTALDLH TDEQAHRPLD TIGGLLNVSL LYHVWLCGVF LLVTWYSSWI LFKIYATEAH 300
VFPVQPPFAE ASDECLPKVL NSNPPRIVKY LALQDLMLLS QYSPSRRQEV FSLSQPGGHP 360
HNWTAISREC LNLLNDMTQK LVLYQEAAAT NGRMYSSYSV EPKKLSSAEE TAFQTPKPSQ 420
TPSVPPLVKT SLFSPKLSTP NVSSPFGTPF GSSVVNRMAG ILDVNPFSGS PQSPQLIRRG 480
PRLWTHTSDQ QVSAISNPSP CASVTAEGKT VRQPSVIYSW IQNKREQIKN FLSKRVLIMY 540
FFSKHPEASI QAVFSDAQMH IWALEGLSHL VAASFTEDRF GVVQTTLPAI LHTLLTLQEA 600
VDKYFKLPHA SSKPPRASGS LVDTSYKTLR FAFRASLKTA IYRITTTFGE HLNAVQASAE 660
HQKRLQQFLE FKE 673 |
Gene Ontology | GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell. GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell. GO:0017056; F:structural constituent of nuclear pore; IEA:Compara. GO:0051028; P:mRNA transport; IEA:UniProtKB-KW. GO:0051292; P:nuclear pore complex assembly; IEA:Compara. GO:0031081; P:nuclear pore distribution; IEA:Compara. GO:0015031; P:protein transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |