UniProt Accession

 ZIC2_HUMAN; O95409; Q5VYA9; Q9H309 

Genbank Protein ID

 AF104902; AF193855; AL355338 

Genbank Nucleotide ID

 AAC96325.1; AAG28409.1; CAH70367.1 

Protein Name

 Zinc finger protein ZIC 2 

Protein Synonyms/Alias

 Zinc finger protein of the cerebellum 2 

Gene Name

 ZIC2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
342	CPFPGCGKVFARSEN	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. 

Sequence Annotation

 ZN_FING 256 291 C2H2-type 1; atypical.
 ZN_FING 300 327 C2H2-type 2; atypical.
 ZN_FING 333 357 C2H2-type 3.
 ZN_FING 363 387 C2H2-type 4.
 ZN_FING 393 415 C2H2-type 5.
 REGION 100 255 Necessary for interaction with MDFIC and
 MOD_RES 191 191 Phosphoserine (By similarity).
 MOD_RES 199 199 Phosphoserine (By similarity).  

Keyword

 Activator; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Disease mutation; DNA-binding; Holoprosencephaly; Metal-binding; Neurogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 532 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007420; P:brain development; TAS:ProtInc.
 GO:0048066; P:developmental pigmentation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0001843; P:neural tube closure; IEA:Compara.
 GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0031290; P:retinal ganglion cell axon guidance; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0007601; P:visual perception; ISS:UniProtKB. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS