CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037176
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 U4/U6 small nuclear ribonucleoprotein Prp31 
Protein Synonyms/Alias
  
Gene Name
 PRPF31 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
395FSLGHLGKSGSGRVRubiquitination[1]
411TQVNEATKARISKTLubiquitination[2]
424TLQRTLQKQSVVYGGubiquitination[2, 3]
432QSVVYGGKSTIRDRSubiquitination[1]
464VNPQAAEKKVAEANQubiquitination[1]
472KVAEANQKYFSSMAEubiquitination[2]
484MAEFLKVKGEKSGLMubiquitination[1]
487FLKVKGEKSGLMST*ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MSLADELLAD LEEAAEEEEG GSYGEEEEEP AIEDVQEETQ LDLSGDSVKT IAKLWDSKMF 60
AEIMMKIEEY ISKQAKASEV MGPVEAAPEY RVIVDANNLT VEIENELNII HKFIRDKYSK 120
RFPELESLVP NALDYIRTVK ELGNSLDKCK NNENLQQILT NATIMVVSVT ASTTQGQQLS 180
EEELERLEEA CDMALELNAS KHRIYEYVES RMSFIAPNLS IIIGASTAAK IMGVAGGLTN 240
LSKMPACNIM LLGAQRKTLS GFSSTSVLPH TGYIYHSDIV QSLPPDLRRK AARLVAAKCT 300
LAARVDSFHE STEGKDEIER KFDKWQEPPP VKQVKPLPAP LDGQRKKRGG RRYRKMKERL 360
GLTEIRKQAN RMSFGEIEED AYQEDLGFSL GHLGKSGSGR VRQTQVNEAT KARISKTLQR 420
TLQKQSVVYG GKSTIRDRSS GTASSVAFTP LQGLEIVNPQ AAEKKVAEAN QKYFSSMAEF 480
LKVKGEKSGL MST 493 
Gene Ontology
 GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:InterPro.
 GO:0000244; P:assembly of spliceosomal tri-snRNP; IEA:InterPro. 
Interpro
 IPR002687; Nop_dom.
 IPR012976; NOSIC.
 IPR027105; Prp31.
 IPR019175; Prp31_C. 
Pfam
 PF01798; Nop
 PF08060; NOSIC
 PF09785; Prp31_C 
SMART
 SM00931; NOSIC 
PROSITE
 PS51358; NOP 
PRINTS