Tag | Content |
---|
CPLM ID | CPLM-016812 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | NF-kappa-B inhibitor-interacting Ras-like protein 1 |
Protein Synonyms/Alias | I-kappa-B-interacting Ras-like protein 1; Kappa B-Ras protein 1; KappaB-Ras1 |
Gene Name | Nkiras1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
---|
67 | YDTRGLQKGVELPKH | ubiquitination | [1] | 167 | PFTLLASKLSQPQSK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). |
Sequence Annotation | NP_BIND 11 18 GTP (By similarity). NP_BIND 61 65 GTP (By similarity). NP_BIND 120 123 GTP (By similarity). REGION 58 93 Interactions with NFKBIA and NFKBIB (By MOTIF 35 43 Effector region. |
Keyword | Complete proteome; Cytoplasm; GTP-binding; Nucleotide-binding; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 192 AA |
Protein Sequence | MGKGCKVVIC GLLSVGKTAI LEQLLYGNHT IGMEDCETLE DVYMASVETD RGVKEQLHLY 60 DTRGLQKGVE LPKHYFSFAD GFVLVYSVNN LESFQRVELL KKEIDKFKDK KEVAIVVLGN 120 KLDLSEQRQV DADVAQQWAR SEKVKLWEVT VTDRRTLIEP FTLLASKLSQ PQSKSSFPLP 180 GRKNKGNSNP EN 192 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |