CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030796
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 
Protein Synonyms/Alias
 cDNA FLJ55202, highly similar to SWI/SNF-related matrix-associatedactin-dependent regulator of chromatin subfamily E member 1 
Gene Name
 SMARCE1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
74KASNPDLKLWEIGKIubiquitination[1, 2, 3, 4, 5, 6, 7]
80LKLWEIGKIIGGMWRubiquitination[5]
113IEYNESMKAYHNSPAubiquitination[1]
128YLAYINAKSRAEAALubiquitination[1, 5]
148QRQSRMEKGEPYMSIubiquitination[5, 6]
171YDDGFSMKHTATARFubiquitination[4, 5, 6]
222SLMVHQRKLEAELLQubiquitination[2, 5, 7]
240RHQEKKRKFLESTDSubiquitination[1, 5, 7]
253DSFNNELKRLCGLKVubiquitination[1, 2, 4, 5, 6, 7]
259LKRLCGLKVEVDMEKubiquitination[5, 7]
266KVEVDMEKIAAEIAQubiquitination[2, 5, 6, 7]
310EEEQAANKGEEKKDDacetylation[8, 9]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [8] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [9] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 393 AA 
Protein Sequence
MPSTPGFVGY NPYSHLAYNN YRLGGNPGTN SRVTASSGIT IPKPPKPPDK PLMPYMRYSR 60
KVWDQVKASN PDLKLWEIGK IIGGMWRDLT DEEKQEYLNE YEAEKIEYNE SMKAYHNSPA 120
YLAYINAKSR AEAALEEESR QRQSRMEKGE PYMSIQPAED PDDYDDGFSM KHTATARFQR 180
NHRLISEILS ESVVPDVRSV VTTARMQVLK RQVQSLMVHQ RKLEAELLQI EERHQEKKRK 240
FLESTDSFNN ELKRLCGLKV EVDMEKIAAE IAQAEEQARK RQEEREKEAA EQAERSQSSI 300
VPEEEQAANK GEEKKDDENI PMETEETHLE ETTESQQNGE EGTSTPEDKE SGQEGVDSMA 360
EEGTSDSNTG SESNSATVEE PPTDPIPEDE KKE 393 
Gene Ontology
 GO:0071565; C:nBAF complex; IEA:Compara.
 GO:0071564; C:npBAF complex; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0016514; C:SWI/SNF complex; IEA:Compara. 
Interpro
 IPR009071; HMG_box_dom. 
Pfam
 PF00505; HMG_box 
SMART
 SM00398; HMG 
PROSITE
 PS50118; HMG_BOX_2 
PRINTS