UniProt Accession

 1433G_RAT; P61983; A0JPM0; O70457; P35214; Q9UDP2; Q9UN99 

Genbank Protein ID

 D17447; S55305; BC127496 

Genbank Nucleotide ID

 BAA04261.1; AAA13844.1; AAI27497.1 

Protein Name

 14-3-3 protein gamma 

Protein Synonyms/Alias

 14-3-3 protein gamma, N-terminally processed 

Gene Name

 Ywhag 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
10	DREQLVQKARLAEQA	acetylation	[1]
10	DREQLVQKARLAEQA	ubiquitination	[2]
28	DDMAAAMKNVTELNE	acetylation	[1]
69	VISSIEQKTSADGNE	acetylation	[1]
69	VISSIEQKTSADGNE	ubiquitination	[2]
77	TSADGNEKKIEMVRA	acetylation	[1]
78	SADGNEKKIEMVRAY	acetylation	[1]
142	AEVATGEKRATVVES	acetylation	[1]
142	AEVATGEKRATVVES	ubiquitination	[2]
152	TVVESSEKAYSEAHE	acetylation	[1]
152	TVVESSEKAYSEAHE	ubiquitination	[2]
162	SEAHEISKEHMQPTH	acetylation	[1]
162	SEAHEISKEHMQPTH	ubiquitination	[2]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 

Sequence Annotation

 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylvaline; in 14-3-3 protein gamma,
 MOD_RES 117 117 Phosphotyrosine (By similarity).
 MOD_RES 145 145 Phosphothreonine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 247 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003779; F:actin binding; ISS:UniProtKB.
 GO:0030234; F:enzyme regulator activity; TAS:RGD.
 GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
 GO:0005080; F:protein kinase C binding; ISS:UniProtKB.
 GO:0006605; P:protein targeting; IEA:Compara.
 GO:0045664; P:regulation of neuron differentiation; ISS:UniProtKB.
 GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
 GO:0007165; P:signal transduction; TAS:RGD. 

Interpro

 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 

Pfam

 PF00244; 14-3-3 

SMART

 SM00101; 14_3_3 

PROSITE

 PS00796; 1433_1
 PS00797; 1433_2 

PRINTS

 PR00305; 1433ZETA.