UniProt Accession

 IDI1_YEAST; P15496; D6W3Q1 

Genbank Protein ID

 J05090; U43503; BK006949 

Genbank Nucleotide ID

 AAA34708.1; AAB68245.1; DAA11317.1 

Protein Name

 Isopentenyl-diphosphate Delta-isomerase 

Protein Synonyms/Alias

 Isopentenyl pyrophosphate isomerase; IPP isomerase 

Gene Name

 IDI1 

Gene Synonyms/Alias

 BOT2; YPL117C; LPH10C 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
169	AITAAVRKLDHELGI	ubiquitination	[1]
219	LFYKINAKENLTVNP	ubiquitination	[1]
243	WVSPNDLKTMFADPS	ubiquitination	[1]
252	MFADPSYKFTPWFKI	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). 

Sequence Annotation

 DOMAIN 102 259 Nudix hydrolase.
 ACT_SITE 139 139 By similarity.
 ACT_SITE 207 207 By similarity.
 METAL 93 93 Magnesium (By similarity).
 METAL 104 104 Magnesium (By similarity).
 METAL 205 205 Magnesium (By similarity).
 METAL 207 207 Magnesium (By similarity).
 BINDING 89 89 Substrate (By similarity).
 BINDING 123 123 Substrate (By similarity).
 BINDING 127 127 Substrate (By similarity).
 BINDING 140 140 Substrate (By similarity).
 MOD_RES 7 7 Phosphoserine.  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Isoprene biosynthesis; Lipid biosynthesis; Lipid metabolism; Magnesium; Metal-binding; Phosphoprotein; Reference proteome; Steroid biosynthesis; Steroid metabolism; Sterol biosynthesis; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 288 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016787; F:hydrolase activity; IEA:InterPro.
 GO:0004452; F:isopentenyl-diphosphate delta-isomerase activity; IDA:SGD.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050992; P:dimethylallyl diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045337; P:farnesyl diphosphate biosynthetic process; IDA:SGD.
 GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. 

Interpro

 IPR011876; IsopentenylPP_isomerase_typ1.
 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX 

PRINTS