CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015415
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane and coiled-coil domain-containing protein 3 
Protein Synonyms/Alias
 Putative LAG1-interacting protein 
Gene Name
 TMCO3 
Gene Synonyms/Alias
 C13orf11; UNQ2419/PRO4976 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
132YKDVVNMKESSRQRLubiquitination[1]
148ALREAAIKEETEYMEubiquitination[1]
210FDDNKSVKGVNFEAVubiquitination[1]
228EEEEANSKQNITKREubiquitination[1]
257NNQYILTKPRDSTIPubiquitination[1, 2, 3]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Probable Na(+)/H(+) antiporter (By similarity). 
Sequence Annotation
 CARBOHYD 206 206 N-linked (GlcNAc...) (Potential).
 CARBOHYD 230 230 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Antiport; Coiled coil; Complete proteome; Glycoprotein; Ion transport; Membrane; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 677 AA 
Protein Sequence
MKVLGRSFFW VLFPVLPWAV QAVEHEEVAQ RVIKLHRGRG VAAMQSRQWV RDSCRKLSGL 60
LRQKNAVLNK LKTAIGAVEK DVGLSDEEKL FQVHTFEIFQ KELNESENSV FQAVYGLQRA 120
LQGDYKDVVN MKESSRQRLE ALREAAIKEE TEYMELLAAE KHQVEALKNM QHQNQSLSML 180
DEILEDVRKA ADRLEEEIEE HAFDDNKSVK GVNFEAVLRV EEEEANSKQN ITKREVEDDL 240
GLSMLIDSQN NQYILTKPRD STIPRADHHF IKDIVTIGML SLPCGWLCTA IGLPTMFGYI 300
ICGVLLGPSG LNSIKSIVQV ETLGEFGVFF TLFLVGLEFS PEKLRKVWKI SLQGPCYMTL 360
LMIAFGLLWG HLLRIKPTQS VFISTCLSLS STPLVSRFLM GSARGDKEGD IDYSTVLLGM 420
LVTQDVQLGL FMAVMPTLIQ AGASASSSIV VEVLRILVLI GQILFSLAAV FLLCLVIKKY 480
LIGPYYRKLH MESKGNKEIL ILGISAFIFL MLTVTELLDV SMELGCFLAG ALVSSQGPVV 540
TEEIATSIEP IRDFLAIVFF ASIGLHVFPT FVAYELTVLV FLTLSVVVMK FLLAALVLSL 600
ILPRSSQYIK WIVSAGLAQV SEFSFVLGSR ARRAGVISRE VYLLILSVTT LSLLLAPVLW 660
RAAITRCVPR PERRSSL 677 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0015299; F:solute:hydrogen antiporter activity; IEA:InterPro. 
Interpro
 IPR006153; Cation/H_exchanger. 
Pfam
 PF00999; Na_H_Exchanger 
SMART
  
PROSITE
  
PRINTS