CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017581
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubiquitin-associated domain-containing protein 2 
Protein Synonyms/Alias
 UBA domain-containing protein 2; Phosphoglycerate dehydrogenase-like protein 1 
Gene Name
 UBAC2 
Gene Synonyms/Alias
 PHGDHL1; PSEC0110 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12TGSSGLYKAPLSKSLubiquitination[1, 2, 3, 4, 5, 6, 7]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 DOMAIN 304 344 UBA.
 CARBOHYD 161 161 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 344 AA 
Protein Sequence
MFTSTGSSGL YKAPLSKSLL LVPSALSLLL ALLLPHCQKL FVYDLHAVKN DFQIWRLICG 60
RIICLDLKDT FCSSLLIYNF RIFERRYGSR KFASFLLGSW VLSALFDFLL IEAMQYFFGI 120
TAASNLPSGF LAPVFALFVP FYCSIPRVQV AQILGPLSIT NKTLIYILGL QLFTSGSYIW 180
IVAISGLMSG LCYDSKMFQV HQVLCIPSWM AKFFSWTLEP IFSSSEPTSE ARIGMGATLD 240
IQRQQRMELL DRQLMFSQFA QGRRQRQQQG GMINWNRLFP PLRQRQNVNY QGGRQSEPAA 300
PPLEVSEEQV ARLMEMGFSR GDALEALRAS NNDLNVATNF LLQH 344 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. 
Interpro
 IPR009060; UBA-like.
 IPR000449; UBA/transl_elong_EF1B_N.
 IPR015940; UBA/transl_elong_EF1B_N_euk. 
Pfam
 PF00627; UBA 
SMART
 SM00165; UBA 
PROSITE
 PS50030; UBA 
PRINTS