| Tag | Content |
|---|
| CPLM ID | CPLM-007923 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Phosphoinositide 3-phosphatase |
Protein Synonyms/Alias | Yeast myotubularin-related protein 1 |
Gene Name | YMR1 |
Gene Synonyms/Alias | YJR110W; J2007 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 82 | GTDSQNYKLYQGKDL | ubiquitination | [1] | | 173 | RRQGLDSKDETCPWR | ubiquitination | [1] |
|
Reference | [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation. Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J. Nat Methods. 2013 Jul;10(7):676-82. [ PMID: 23749301] |
Functional Description | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P). Involved in the control of PI3P-dependent signaling and in the maintenance of endosomal system integrity. |
Sequence Annotation | DOMAIN 155 637 Myotubularin phosphatase.
ACT_SITE 397 397 Phosphocysteine intermediate (By |
Keyword | Complete proteome; Cytoplasm; Hydrolase; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 688 AA |
Protein Sequence | MEYIKIAKVS NVVLHRRGTA TQGTLHLTTH HLIFESPQLS TEFWFPYPLI YGVHKNPGST 60
LLSKLTSTNQ IQLEGTDSQN YKLYQGKDLW SFVNIKVIGK DYAVFSLDFG GDLHLQARKV 120
YDSILNLTVL SNITQLYAFI YISNNLERKL PSPDSWDIYD PIKEFRRQGL DSKDETCPWR 180
LSTVNEHYEF CPTYPSKLFV PRSTSDILLK HASKFRSQKR IPVLTYHHKA TDCNILRSSQ 240
PLPGLINQRS IQDEKLVWES FNSFCNKDIR RTKHVIVDAR PRTNALAQMA LGGGTENMDN 300
YNFFLADNNM GVDKSLKLPT VTRLFLGIDN IHIVSNTAAY MTEVICQGGD LNLPLEQNLI 360
RSQKFSNWLK LNTLILKSVD MLLKSIIFNH SNVLVHCSDG WDRTSQVVSL LEICLDPFYR 420
TFEGFMILVE KDWCSFGHRF LERSGHLNSD IRFHDNTMHS NFNDVDTNGD DLDIGVNTQD 480
DYAEDDEGGE DETNLINLSR ISKKFNENFK LNKKSLKFVS PVFQQFLDCV YQLLTQNPDL 540
FEFNERFLRR LVYHLYSCQY GTFLSNSEKE KFQQNLPNKT KSVWDYFRSR RKQFINPNFI 600
QRKRSGMNEH DQNLEEEEKV EWISPDLKKV QWWWQLYGRK DSEMNDELRH KRDSVPISVD 660
KKSKEHSNSD GGKGLNLSIF GFDMFNRK 688 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:SGD. GO:0003729; F:mRNA binding; IDA:SGD. GO:0004438; F:phosphatidylinositol-3-phosphatase activity; IMP:UniProtKB. GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro. GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC. GO:0046856; P:phosphatidylinositol dephosphorylation; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |