CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042708
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Thioredoxin reductase 3 
Protein Synonyms/Alias
  
Gene Name
 TXNRD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
173LSEITNQKTVPNIFVubiquitination[1]
284QALCDSRKFGWEYNQubiquitination[1]
460VMVQQLEKGSPGKLKubiquitination[1]
507GLEKIGVKINEKSGKubiquitination[1]
656QGFAAAMKCGLTKQLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; FAD; Flavoprotein; Oxidoreductase; Redox-active center; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 698 AA 
Protein Sequence
GVGGRGERLP RGFARVVRVA SEGSVRRPSG PVPAPQPPAF RFVSRPGRAR SESETLERSP 60
PQSPGPGKAG DAPNRRSGHV RGARVLSPPG RRARLSSPGP SRSSEAREEL RRHLVGLIER 120
SRVVIFSKSY CPHSTRVKEL FSSLGVECNV LELDQVDDGA RVQEVLSEIT NQKTVPNIFV 180
NKVHVGGCDQ TFQAYQSGLL QKLLQEDLAY DYDLIIIGGG SGGLSCAKEA AILGKKVMVL 240
DFVVPSPQGT SWGLGGTCVN VGCIPKKLMH QAALLGQALC DSRKFGWEYN QQVRHNWETM 300
TKAIQNHISS LNWGYRLSLR EKAVAYVNSY GEFVEHHKIK ATNKKGQETY YTAAQFVIAT 360
GERPRYLGIQ GDKEYCITSD DLFSLPYCPG KTLVVGASYV ALECAGFLAG FGLDVTVMVR 420
SILLRGFDQE MAEKVGSYME QHGVKFLRKF IPVMVQQLEK GSPGKLKVLA KSTEGTETIE 480
GVYNTVLLAI GRDSCTRKIG LEKIGVKINE KSGKIPVNDV EQTNVPYVYA VGDILEDKPE 540
LTPVAIQSGK LLAQRLFGAS LEKCDYINVP TTVFTPLEYG CCGLSEEKAI EVYKKENLEI 600
YHTLFWPLEW TVAGRENNTC YAKIICNKFD HDRVIGFHIL GPNAGEVTQG FAAAMKCGLT 660
KQLLDDTIGI HPTCGEVFTT LEITKSSGLD ITQKGCCG 698 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:InterPro.
 GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
 GO:0004791; F:thioredoxin-disulfide reductase activity; IEA:InterPro.
 GO:0045454; P:cell redox homeostasis; IEA:InterPro. 
Interpro
 IPR016156; FAD/NAD-linked_Rdtase_dimer.
 IPR013027; FAD_pyr_nucl-diS_OxRdtase.
 IPR002109; Glutaredoxin.
 IPR011899; Glutaredoxin_euk/vir.
 IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
 IPR023753; Pyr_nucl-diS_OxRdtase_FAD/NAD.
 IPR012999; Pyr_OxRdtase_I_AS.
 IPR001327; Pyr_OxRdtase_NAD-bd_dom.
 IPR012336; Thioredoxin-like_fold.
 IPR006338; Thioredoxin/glutathione_Rdtase. 
Pfam
 PF00462; Glutaredoxin
 PF00070; Pyr_redox
 PF07992; Pyr_redox_2
 PF02852; Pyr_redox_dim 
SMART
  
PROSITE
 PS51354; GLUTAREDOXIN_2
 PS00076; PYRIDINE_REDOX_1 
PRINTS
 PR00368; FADPNR.