UniProt Accession

 YACG_SALTY; P67481; Q8XFY1 

Genbank Protein ID

 AE006468 

Genbank Nucleotide ID

 AAL19102.1 

Protein Name

 DNA gyrase inhibitor YacG 

Protein Synonyms/Alias

  

Gene Name

 yacG 

Gene Synonyms/Alias

 STM0138 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
45	GEWAAEEKRIASSGD	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity). 

Sequence Annotation

 METAL 9 9 Zinc (By similarity).
 METAL 12 12 Zinc (By similarity).
 METAL 28 28 Zinc (By similarity).
 METAL 32 32 Zinc (By similarity).  

Keyword

 Complete proteome; Metal-binding; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 63 AA 

Protein Sequence

Gene Ontology

 GO:0008657; F:DNA topoisomerase (ATP-hydrolyzing) inhibitor activity; IEA:HAMAP.
 GO:0008270; F:zinc ion binding; IEA:HAMAP.
 GO:2000372; P:negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity; IEA:GOC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR005584; DNA_gyrase_inhibitor_YacG.
 IPR013088; Znf_NHR/GATA. 

Pfam

 PF03884; DUF329 

SMART

  

PROSITE

  

PRINTS