CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004408
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Atrial natriuretic peptide receptor 1 
Protein Synonyms/Alias
 Atrial natriuretic peptide receptor type A; ANP-A; ANPR-A; NPR-A; Guanylate cyclase A; GC-A 
Gene Name
 NPR1 
Gene Synonyms/Alias
 ANPRA 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
67ELALAQVKARPDLLPubiquitination[1]
149PALGFGVKDEYALTTubiquitination[1]
749EGLDLSPKEIIERVTubiquitination[1]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. 
Sequence Annotation
 DOMAIN 528 805 Protein kinase.
 DOMAIN 876 1006 Guanylate cyclase.
 BINDING 85 85 Chloride (By similarity).
 BINDING 117 117 Chloride; via amide nitrogen (By
 BINDING 118 118 Chloride; via amide nitrogen (By
 MOD_RES 519 519 Phosphoserine.
 MOD_RES 529 529 Phosphoserine.
 MOD_RES 532 532 Phosphothreonine.
 MOD_RES 534 534 Phosphoserine.
 MOD_RES 538 538 Phosphoserine.
 MOD_RES 542 542 Phosphoserine (By similarity).
 MOD_RES 545 545 Phosphothreonine (By similarity).
 CARBOHYD 34 34 N-linked (GlcNAc...) (Potential).
 CARBOHYD 45 45 N-linked (GlcNAc...) (Potential).
 CARBOHYD 212 212 N-linked (GlcNAc...) (Potential).
 CARBOHYD 338 338 N-linked (GlcNAc...) (Potential).
 CARBOHYD 379 379 N-linked (GlcNAc...) (Potential).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 CARBOHYD 427 427 N-linked (GlcNAc...) (Potential).
 DISULFID 92 118 By similarity.
 DISULFID 196 245 By similarity.
 DISULFID 455 464 By similarity.  
Keyword
 cGMP biosynthesis; Chloride; Complete proteome; Disulfide bond; Glycoprotein; GTP-binding; Lyase; Membrane; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; Vasoactive. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1061 AA 
Protein Sequence
MPGPRRPAGS RLRLLLLLLL PPLLLLLRGS HAGNLTVAVV LPLANTSYPW SWARVGPAVE 60
LALAQVKARP DLLPGWTVRT VLGSSENALG VCSDTAAPLA AVDLKWEHNP AVFLGPGCVY 120
AAAPVGRFTA HWRVPLLTAG APALGFGVKD EYALTTRAGP SYAKLGDFVA ALHRRLGWER 180
QALMLYAYRP GDEEHCFFLV EGLFMRVRDR LNITVDHLEF AEDDLSHYTR LLRTMPRKGR 240
VIYICSSPDA FRTLMLLALE AGLCGEDYVF FHLDIFGQSL QGGQGPAPRR PWERGDGQDV 300
SARQAFQAAK IITYKDPDNP EYLEFLKQLK HLAYEQFNFT MEDGLVNTIP ASFHDGLLLY 360
IQAVTETLAH GGTVTDGENI TQRMWNRSFQ GVTGYLKIDS SGDRETDFSL WDMDPENGAF 420
RVVLNYNGTS QELVAVSGRK LNWPLGYPPP DIPKCGFDNE DPACNQDHLS TLEVLALVGS 480
LSLLGILIVS FFIYRKMQLE KELASELWRV RWEDVEPSSL ERHLRSAGSR LTLSGRGSNY 540
GSLLTTEGQF QVFAKTAYYK GNLVAVKRVN RKRIELTRKV LFELKHMRDV QNEHLTRFVG 600
ACTDPPNICI LTEYCPRGSL QDILENESIT LDWMFRYSLT NDIVKGMLFL HNGAICSHGN 660
LKSSNCVVDG RFVLKITDYG LESFRDLDPE QGHTVYAKKL WTAPELLRMA SPPVRGSQAG 720
DVYSFGIILQ EIALRSGVFH VEGLDLSPKE IIERVTRGEQ PPFRPSLALQ SHLEELGLLM 780
QRCWAEDPQE RPPFQQIRLT LRKFNRENSS NILDNLLSRM EQYANNLEEL VEERTQAYLE 840
EKRKAEALLY QILPHSVAEQ LKRGETVQAE AFDSVTIYFS DIVGFTALSA ESTPMQVVTL 900
LNDLYTCFDA VIDNFDVYKV ETIGDAYMVV SGLPVRNGRL HACEVARMAL ALLDAVRSFR 960
IRHRPQEQLR LRIGIHTGPV CAGVVGLKMP RYCLFGDTVN TASRMESNGE ALKIHLSSET 1020
KAVLEEFGGF ELELRGDVEM KGKGKVRTYW LLGERGSSTR G 1061 
Gene Ontology
 GO:0005887; C:integral to plasma membrane; IC:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0008528; F:G-protein coupled peptide receptor activity; NAS:UniProtKB.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004383; F:guanylate cyclase activity; IDA:UniProtKB.
 GO:0042562; F:hormone binding; IPI:UniProtKB.
 GO:0016941; F:natriuretic peptide receptor activity; IDA:UniProtKB.
 GO:0017046; F:peptide hormone binding; IEA:Compara.
 GO:0004672; F:protein kinase activity; IEA:InterPro.
 GO:0007589; P:body fluid secretion; TAS:UniProtKB.
 GO:0042417; P:dopamine metabolic process; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; IEA:Compara.
 GO:0016525; P:negative regulation of angiogenesis; TAS:UniProtKB.
 GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.
 GO:0048662; P:negative regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0030828; P:positive regulation of cGMP biosynthetic process; IEA:Compara.
 GO:0035815; P:positive regulation of renal sodium excretion; TAS:UniProtKB.
 GO:0035810; P:positive regulation of urine volume; TAS:UniProtKB.
 GO:0007168; P:receptor guanylyl cyclase signaling pathway; IDA:UniProtKB.
 GO:0008217; P:regulation of blood pressure; NAS:UniProtKB.
 GO:0050880; P:regulation of blood vessel size; IEA:UniProtKB-KW.
 GO:0043114; P:regulation of vascular permeability; TAS:UniProtKB.
 GO:0042312; P:regulation of vasodilation; NAS:UniProtKB. 
Interpro
 IPR001054; A/G_cyclase.
 IPR018297; A/G_cyclase_CS.
 IPR001828; ANF_lig-bd_rcpt.
 IPR011009; Kinase-like_dom.
 IPR001170; Ntpep_rcpt.
 IPR000719; Prot_kinase_cat_dom.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom. 
Pfam
 PF01094; ANF_receptor
 PF00211; Guanylate_cyc
 PF07714; Pkinase_Tyr 
SMART
 SM00044; CYCc 
PROSITE
 PS00458; ANF_RECEPTORS
 PS00452; GUANYLATE_CYCLASE_1
 PS50125; GUANYLATE_CYCLASE_2
 PS50011; PROTEIN_KINASE_DOM 
PRINTS
 PR00255; NATPEPTIDER.