UniProt Accession

 DHAS_SALTY; P0A1F8; O30706 

Genbank Protein ID

 AF015781; AE006468 

Genbank Nucleotide ID

 AAB69392.1; AAL22399.1 

Protein Name

 Aspartate-semialdehyde dehydrogenase 

Protein Synonyms/Alias

 ASA dehydrogenase; ASADH; Aspartate-beta-semialdehyde dehydrogenase 

Gene Name

 asd 

Gene Synonyms/Alias

 STM3539 

Created Date

 July 27, 2013 

Organism

 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 

NCBI Taxa ID

 99287 

Lysine Modification

Position	Peptide	Type	References
285	AFTIKLKKEVSIPTV	acetylation	[1]

Reference

 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity). 

Sequence Annotation

 NP_BIND 10 13 NADP (By similarity).
 NP_BIND 37 38 NADP (By similarity).
 NP_BIND 166 167 NADP (By similarity).
 ACT_SITE 136 136 Acyl-thioester intermediate (By
 ACT_SITE 275 275 Proton acceptor (By similarity).
 BINDING 74 74 NADP (By similarity).
 BINDING 103 103 Phosphate (By similarity).
 BINDING 163 163 Substrate (By similarity).
 BINDING 194 194 NADP; via carbonyl oxygen (By
 BINDING 242 242 Substrate (By similarity).
 BINDING 245 245 Phosphate (By similarity).
 BINDING 268 268 Substrate (By similarity).
 BINDING 351 351 NADP (By similarity).
 MOD_RES 136 136 S-cysteinyl cysteine; in inhibited form  

Keyword

 Amino-acid biosynthesis; Complete proteome; Diaminopimelate biosynthesis; Lysine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Reference proteome; Threonine biosynthesis. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 368 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0004073; F:aspartate-semialdehyde dehydrogenase activity; IEA:HAMAP.
 GO:0003942; F:N-acetyl-gamma-glutamyl-phosphate reductase activity; IEA:InterPro.
 GO:0051287; F:NAD binding; IEA:InterPro.
 GO:0050661; F:NADP binding; IEA:HAMAP.
 GO:0071266; P:'de novo' L-methionine biosynthetic process; IEA:HAMAP.
 GO:0019877; P:diaminopimelate biosynthetic process; IEA:HAMAP.
 GO:0009097; P:isoleucine biosynthetic process; IEA:InterPro.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP.
 GO:0009088; P:threonine biosynthetic process; IEA:HAMAP. 

Interpro

 IPR000319; Asp-semialdehyde_DH_CS.
 IPR011534; Asp_ADH_gamma-type.
 IPR012080; Asp_semialdehyde_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR000534; Semialdehyde_DH_NAD-bd.
 IPR012280; Semialdhyde_DH_dimer_dom. 

Pfam

 PF01118; Semialdhyde_dh
 PF02774; Semialdhyde_dhC 

SMART

 SM00859; Semialdhyde_dh 

PROSITE

 PS01103; ASD 

PRINTS