| Tag | Content |
|---|
| CPLM ID | CPLM-019223 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Microspherule protein 1 |
Protein Synonyms/Alias | 58 kDa microspherule protein; Cell cycle-regulated factor p78; INO80 complex subunit J; MCRS2 |
Gene Name | MCRS1 |
Gene Synonyms/Alias | INO80Q; MSP58 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 143 | KQPLQVTKDLGRWKP | ubiquitination | [1] | | 219 | AIAAIQSKALFSKAE | ubiquitination | [1] | | 224 | QSKALFSKAEEQLLS | ubiquitination | [1] | | 232 | AEEQLLSKVGSTSQP | ubiquitination | [1] | | 383 | ITLGRATKDNQIDVD | ubiquitination | [1] | | 410 | KQGVIKLKNNGDFFI | ubiquitination | [1] | | 471 | LIRAEAAKITPQ*** | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity. |
Sequence Annotation | DOMAIN 363 419 FHA.
MOTIF 113 123 Nuclear localization signal (Potential).
MOD_RES 22 22 Phosphoserine.
MOD_RES 103 103 Phosphothreonine.
MOD_RES 108 108 Phosphoserine.
MOD_RES 123 123 N6-acetyllysine.
MOD_RES 130 130 N6-acetyllysine.
MOD_RES 282 282 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Chromatin regulator; Coiled coil; Complete proteome; DNA damage; DNA recombination; DNA repair; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 462 AA |
Protein Sequence | MTRGTGGTAQ RGRSGPDSQG LLDSSLMASG TASRSEDEES LAGQKRASSQ ALGTIPKRRS 60
SSRFIKRKKF DDELVESSLA KSSTRAKGAS GVEPGRCSGS EPSSSEKKKV SKAPSTPVPP 120
SPAPAPGLTK RVKKSKQPLQ VTKDLGRWKP ADDLLLINAV LQTNDLTSVH LGVKFSCRFT 180
LREVQERWYA LLYDPVISKL ACQAMRQLHP EAIAAIQSKA LFSKAEEQLL SKVGSTSQPT 240
LETFQDLLHR HPDAFYLART AKALQAHWQL MKQYYLLEDQ TVQPLPKGDQ VLNFSDAEDL 300
IDDSKLKDMR DEVLEHELMV ADRRQKREIR QLEQELHKWQ VLVDSITGMS SPDFDNQTLA 360
VLRGRMVRYL MRSREITLGR ATKDNQIDVD LSLEGPAWKI SRKQGVIKLK NNGDFFIANE 420
GRRPIYIDGR PVLCGSKWRL SNNSVVEIAS LRFVFLINQD LIALIRAEAA KITPQ 475 |
Gene Ontology | GO:0005737; C:cytoplasm; TAS:ProtInc. GO:0000123; C:histone acetyltransferase complex; IDA:UniProtKB. GO:0031011; C:Ino80 complex; IDA:UniProtKB. GO:0071339; C:MLL1 complex; IDA:UniProtKB. GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. GO:0006281; P:DNA repair; IEA:UniProtKB-KW. GO:0043984; P:histone H4-K16 acetylation; IDA:UniProtKB. GO:0043981; P:histone H4-K5 acetylation; IDA:UniProtKB. GO:0043982; P:histone H4-K8 acetylation; IDA:UniProtKB. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
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