UniProt Accession

 SPHM_HUMAN; P51688; A8K5E2 

Genbank Protein ID

 U30894; U60111; U60107; U60108; U60109; U60110; AK291257; BC047318 

Genbank Nucleotide ID

 AAA86530.1; AAB17952.1; AAB17952.1; AAB17952.1; AAB17952.1; AAB17952.1; BAF83946.1; AAH47318.1 

Protein Name

 N-sulphoglucosamine sulphohydrolase 

Protein Synonyms/Alias

 Sulfoglucosamine sulfamidase; Sulphamidase 

Gene Name

 SGSH 

Gene Synonyms/Alias

 HSS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
103	HHFNSFDKVRSLPLL	ubiquitination	[1, 2]
303	VSSPEHPKRWGQVSE	ubiquitination	[1, 2, 3]
425	GQPTGWYKDLRHYYY	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 METAL 31 31 Calcium (By similarity).
 METAL 32 32 Calcium (By similarity).
 METAL 70 70 Calcium; via 3-oxoalanine (By
 METAL 273 273 Calcium (By similarity).
 METAL 274 274 Calcium (By similarity).
 MOD_RES 70 70 3-oxoalanine (Cys) (By similarity).
 CARBOHYD 41 41 N-linked (GlcNAc...).
 CARBOHYD 142 142 N-linked (GlcNAc...) (Potential).
 CARBOHYD 151 151 N-linked (GlcNAc...) (Potential).
 CARBOHYD 264 264 N-linked (GlcNAc...).
 CARBOHYD 413 413 N-linked (GlcNAc...).  

Keyword

 Calcium; Complete proteome; Direct protein sequencing; Disease mutation; Glycoprotein; Hydrolase; Lysosome; Metal-binding; Mucopolysaccharidosis; Polymorphism; Reference proteome; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 502 AA 

Protein Sequence

Gene Ontology

 GO:0043202; C:lysosomal lumen; TAS:Reactome.
 GO:0003824; F:catalytic activity; TAS:ProtInc.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016250; F:N-sulfoglucosamine sulfohydrolase activity; IEA:EC.
 GO:0008484; F:sulfuric ester hydrolase activity; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; TAS:Reactome.
 GO:0006027; P:glycosaminoglycan catabolic process; TAS:Reactome.
 GO:0006029; P:proteoglycan metabolic process; TAS:ProtInc.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR017849; Alkaline_Pase-like_a/b/a.
 IPR017850; Alkaline_phosphatase_core.
 IPR000917; Sulfatase.
 IPR024607; Sulfatase_CS. 

Pfam

 PF00884; Sulfatase 

SMART

  

PROSITE

 PS00523; SULFATASE_1
 PS00149; SULFATASE_2 

PRINTS