UniProt Accession

 ARMET_DROME; Q9XZ63; Q9VEW4 

Genbank Protein ID

 AF132912; AE014297; AY061080 

Genbank Nucleotide ID

 AAD32615.1; AAF55303.1; AAL28628.1 

Protein Name

 Mesencephalic astrocyte-derived neurotrophic factor homolog 

Protein Synonyms/Alias

 DmMANF; MANF/CDNF-like protein 

Gene Name

 Manf 

Gene Synonyms/Alias

 ARP-like; CG7013 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
51	DSTKKDYKQIETAFK	acetylation	[1]

Reference

 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 

Functional Description

 Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels. 

Sequence Annotation

 DISULFID 28 114 By similarity.
 DISULFID 31 103 By similarity.
 DISULFID 61 72 By similarity.
 DISULFID 148 151 By similarity.  

Keyword

 Complete proteome; Developmental protein; Disulfide bond; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 173 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IDA:FlyBase.
 GO:0070050; P:neuron homeostasis; IMP:FlyBase.
 GO:0031175; P:neuron projection development; IMP:FlyBase.
 GO:0001963; P:synaptic transmission, dopaminergic; IMP:UniProtKB. 

Interpro

 IPR019345; Armet_prot.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR011001; Saposin-like. 

Pfam

 PF10208; Armet 

SMART

  

PROSITE

  

PRINTS