CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-023363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable ATP-dependent RNA helicase pitchoune 
Protein Synonyms/Alias
  
Gene Name
 pit 
Gene Synonyms/Alias
 CG6375 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
466PVTSIHGKQKQTKRTacetylation[1]
654GGGFGFYKKMNEGSAacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Probable RNA-dependent helicase. Functions in cell growth and proliferation. May have a role in ribosome biogenesis and, consequently, in protein biosynthesis. 
Sequence Annotation
 DOMAIN 218 393 Helicase ATP-binding.
 DOMAIN 407 577 Helicase C-terminal.
 NP_BIND 231 238 ATP (By similarity).
 MOTIF 187 215 Q motif.
 MOTIF 341 344 DEVD box.  
Keyword
 ATP-binding; Complete proteome; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 680 AA 
Protein Sequence
MSIREKLLMK KIVKREKMKK ELSQKKGNKN AQKQEPPKQN GNKPSKKPEK LSKKHVAKDE 60
DDDLEEDFQE APLPKKKQQK QPPKKQQIQV ANSDSESDDD EQEDEADEDS DLDEVAEVDE 120
EDVDSGSEDD DQQEDEDEEE PVPAKKTKLL PNKSKAQNGK PAKDDEPFTV ESSLAALDYR 180
DSDDRSFASL KGAVSEATLR AIKEMGFTEM TEIQSKSLTP LLKGRDLVGA AQTGSGKTLA 240
FLIPAVELIN KLRFMPRNGT GVIIISPTRE LSMQTFGVLK ELMAHHHHTY GLVMGGSNRQ 300
VESEKLGKGI NILVATPGRL LDHLQNSPDF LYKNLQCLII DEVDRILEIG FEEELKQIIN 360
LLPKRRQTML FSATQTARIE ALSKLALKSE PIYVGVHDNQ DTATVDGLEQ GYIVCPSEKR 420
LLVLFTFLKK NRKKKVMVFF SSCMSVKYHH ELFNYIDLPV TSIHGKQKQT KRTTTFFQFC 480
NAESGILLCT DVAARGLDIP QVDWIVQYDP PDDPREYIHR VGRTARGSGT SGHALLLMRP 540
EELGFLRYLK AAKVPLNEFE FSWQKIADIQ LQLEKLIAKN YFLNQSAKEA FKSYVRAYDS 600
HQLKQIFNVN TLDLQAVAKS FGFLVPPVVD LKVGAAKRER PEKRVGGGGF GFYKKMNEGS 660
ASKQRHFKQV NRDQAKKFMR 680 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003724; F:RNA helicase activity; ISS:FlyBase.
 GO:0016049; P:cell growth; IMP:FlyBase.
 GO:0008283; P:cell proliferation; IMP:FlyBase. 
Interpro
 IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
 IPR025313; DUF4217.
 IPR014001; Helicase_ATP-bd.
 IPR001650; Helicase_C.
 IPR027417; P-loop_NTPase.
 IPR014014; RNA_helicase_DEAD_Q_motif. 
Pfam
 PF00270; DEAD
 PF13959; DUF4217
 PF00271; Helicase_C 
SMART
 SM00487; DEXDc
 SM00490; HELICc 
PROSITE
 PS00039; DEAD_ATP_HELICASE
 PS51192; HELICASE_ATP_BIND_1
 PS51194; HELICASE_CTER
 PS51195; Q_MOTIF 
PRINTS