CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-045055
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 DNA (cytosine-5)-methyltransferase 1 
Protein Synonyms/Alias
  
Gene Name
 DNMT1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
259CSCVEAGKACDPAARubiquitination[1, 2, 3, 4]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 389 AA 
Protein Sequence
XCQGFSGMNR FNSRTYSKFK NSLVVSFLSY CDYYRPRFFL LENVRNFVSF KRSMVLKLTL 60
RCLVRMGYQC TFGVLQAGQY GVAQTRRRAI ILAAAPGEKL PLFPEPLHVF APRACQLSVV 120
VDDKKFVSNI TRLSSGPFRT ITVRDTMSDL PEVRNGASAL EISYNGEPQS WFQRQLRGAQ 180
YQPILRDHIC KDMSALVAAR MRHIPLAPGS DWRDLPNIEV RLSDGTMARK LRYTHHDRKN 240
GRSSSGALRG VCSCVEAGKA CDPAARQFNT LIPWCLPHTG NRHNHWAGLY GRLEWDGFFS 300
TTVTNPEPMG KQGRVLHPEQ HRVVSVRECA RSQGFPDTYR LFGNILDKHR QVSGAAPAGS 360
GQEGGFCACH QVGLGPAQSL PGGRLLAAG 389 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0008168; F:methyltransferase activity; IEA:InterPro.
 GO:0006306; P:DNA methylation; IEA:InterPro. 
Interpro
 IPR001525; C5_MeTfrase. 
Pfam
 PF00145; DNA_methylase 
SMART
  
PROSITE
  
PRINTS
 PR00105; C5METTRFRASE.