UniProt Accession

 SETD4_HUMAN; Q9NVD3; B4DT14; D3DSG2; D3DSG4; Q8NE19; Q9BU46 

Genbank Protein ID

 AF391112; AK001660; AK300009; AP000688; CH471079; CH471079; CH471079; CH471079; CH471079; BC002898; BC036556 

Genbank Nucleotide ID

 AAL34503.1; BAA91819.1; BAG61826.1; EAX09757.1; EAX09758.1; EAX09759.1; EAX09760.1; EAX09762.1; AAH02898.1; AAH36556.1 

Protein Name

 SET domain-containing protein 4 

Protein Synonyms/Alias

  

Gene Name

 SETD4 

Gene Synonyms/Alias

 C21orf18; C21orf27 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
44	RKWLKARKFQDSNLA	ubiquitination	[1]
127	AGHRSLWKPYLEILP	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 DOMAIN 48 273 SET.  

Keyword

 Alternative splicing; Complete proteome; Methyltransferase; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 440 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR016852; Lys_MTase_YDR198C_prd.
 IPR015353; Rubisco_LSMT_subst-bd.
 IPR001214; SET_dom. 

Pfam

 PF09273; Rubis-subs-bind
 PF00856; SET 

SMART

  

PROSITE

 PS50280; SET 

PRINTS