CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015932
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 HAUS augmin-like complex subunit 6 
Protein Synonyms/Alias
  
Gene Name
 HAUS6 
Gene Synonyms/Alias
 DGT6; FAM29A; KIAA1574 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
91KSDTEFRKHCCEWIKubiquitination[1]
98KHCCEWIKRISGECGubiquitination[1]
189RQDCVTQKYQENAQLubiquitination[1]
199ENAQLSVKQVRNLRSubiquitination[1, 2, 3]
216IGLENQIKKMEPYDDubiquitination[1]
217GLENQIKKMEPYDDHubiquitination[1]
283IPRLLLDKIEKQMFQubiquitination[1, 2]
339VDLHYLEKETKFQKEubiquitination[1]
352KERLSDLKHMRYRIKubiquitination[1, 2]
359KHMRYRIKDDLTTIRubiquitination[1]
372IRHSVVEKQGEWHKKubiquitination[1]
381GEWHKKWKEFLGLSPubiquitination[1]
498KNEAISKKIPEFEVEubiquitination[1, 2]
514SPLSDVAKNTESSAFubiquitination[1]
528FGGSLPAKKSDPFQKubiquitination[2, 3]
529GGSLPAKKSDPFQKEubiquitination[1]
535KKSDPFQKEQDHLVEubiquitination[1]
559SPQLSEGKEIKLEELubiquitination[1, 2]
598EIRSSWRKAIEMEENubiquitination[1]
608EMEENRTKEPIQMDAubiquitination[1, 2]
668DCECVPQKHVLTSHIubiquitination[1]
689NQSDLLNKKVICKQDubiquitination[1, 2]
690QSDLLNKKVICKQDLubiquitination[1]
694LNKKVICKQDLECLAubiquitination[1]
704LECLAFTKLSETSRMubiquitination[1]
734GSEEEFMKILDHLEVubiquitination[1]
745HLEVSCNKPSTNKTMubiquitination[1]
847LKKSLSKKREESYLSubiquitination[1, 2]
863SQTPERHKPELSPTPubiquitination[1]
893DLHTEHIKPSLRTSIubiquitination[1]
912RSLSPLIKFSPVEQRubiquitination[1]
935LGELPNLKEEDILNKubiquitination[1]
942KEEDILNKSLDAKEPubiquitination[1]
947LNKSLDAKEPPSDLTubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Promotes the nucleation of microtubules from the spindle through recruitment of NEDD1 and gamma-tubulin. 
Sequence Annotation
 MOD_RES 406 406 Phosphoserine.
 MOD_RES 507 507 Phosphoserine.
 MOD_RES 552 552 Phosphoserine.
 MOD_RES 584 584 Phosphothreonine.
 MOD_RES 715 715 Phosphoserine.
 MOD_RES 805 805 Phosphoserine.  
Keyword
 Alternative splicing; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Mitosis; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 955 AA 
Protein Sequence
MSSASVTAFE KEHLWMYLQA LGFEPGPATI ACGKIVSHTH LGVNMFDKLN RDAFHIISYF 60
LFQVLDQSLT KEVFKFCWPP FDQKSDTEFR KHCCEWIKRI SGECGSSFPQ VVGSLFLSPG 120
GPKFIHLMYH FARFVAMKYI KSNSKNSSHH FVETFNIKPQ DLHKCIARCH FARSRFLQIL 180
QRQDCVTQKY QENAQLSVKQ VRNLRSECIG LENQIKKMEP YDDHSNMEEK IQKVRSLWAS 240
VNETLMFLEK EREVVSSVLS LVNQYALDGT NVAINIPRLL LDKIEKQMFQ LHIGNVYEAG 300
KLNLLTVIQL LNEVLKVMKY ERCQADQARL TVDLHYLEKE TKFQKERLSD LKHMRYRIKD 360
DLTTIRHSVV EKQGEWHKKW KEFLGLSPFS LIKGWTPSVD LLPPMSPLSF DPASEEVYAK 420
SILCQYPASL PDAHKQHNQE NGCRGDSDTL GALHDLANSP ASFLSQSVSS SDRNSVTVLE 480
KDTKMGTPKE KNEAISKKIP EFEVENSPLS DVAKNTESSA FGGSLPAKKS DPFQKEQDHL 540
VEEVARAVLS DSPQLSEGKE IKLEELIDSL GSNPFLTRNQ IPRTPENLIT EIRSSWRKAI 600
EMEENRTKEP IQMDAEHREV LPESLPVLHN QREFSMADFL LETTVSDFGQ SHLTEEKVIS 660
DCECVPQKHV LTSHIDEPPT QNQSDLLNKK VICKQDLECL AFTKLSETSR METFSPAVGN 720
RIDVMGGSEE EFMKILDHLE VSCNKPSTNK TMLWNSFQIS SGISSKSFKD NDFGILHETL 780
PEEVGHLSFN SSSSSEANFK LEPNSPMHGG TLLEDVVGGR QTTPESDFNL QALRSRYEAL 840
KKSLSKKREE SYLSNSQTPE RHKPELSPTP QNVQTDDTLN FLDTCDLHTE HIKPSLRTSI 900
GERKRSLSPL IKFSPVEQRL RTTIACSLGE LPNLKEEDIL NKSLDAKEPP SDLTR 955 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0070652; C:HAUS complex; IDA:UniProtKB.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0051297; P:centrosome organization; IMP:UniProtKB.
 GO:0007067; P:mitosis; IEA:UniProtKB-KW.
 GO:0051225; P:spindle assembly; IMP:UniProtKB. 
Interpro
 IPR026797; HAUS_6. 
Pfam
  
SMART
  
PROSITE
  
PRINTS