UniProt Accession

 SPA2_YEAST; P23201; D6VXY3 

Genbank Protein ID

 X53731; X97560; Z73126; BK006945 

Genbank Nucleotide ID

 CAA37763.1; CAA66170.1; CAA97469.1; DAA09299.1 

Protein Name

 Protein SPA2 

Protein Synonyms/Alias

  

Gene Name

 SPA2 

Gene Synonyms/Alias

 PEA1; YLL021W; L1209 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
143	PMKQEVSKDSDDTAR	ubiquitination	[1]
212	MDEKKEAKPALNPIV	ubiquitination	[1]
522	LIDSAKIKSDSNGES	ubiquitination	[1]
700	ENTEEDNKRSDITNE	ubiquitination	[1]
862	EPSEMPEKGASVESV	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Involved in pheromone-induced morphogenesis and efficient mating, perhaps as a cytoskeletal protein. 

Sequence Annotation

 REPEAT 818 825 1.
 REPEAT 826 834 2.
 REPEAT 835 843 3.
 REPEAT 860 868 4.
 REPEAT 875 883 5.
 REPEAT 884 892 6.
 REPEAT 893 901 7.
 REPEAT 902 910 8.
 REPEAT 911 919 9.
 REPEAT 920 928 10.
 REPEAT 929 937 11.
 REPEAT 938 946 12.
 REPEAT 947 953 13.
 REPEAT 954 961 14.
 REPEAT 962 970 15.
 REPEAT 971 979 16.
 REPEAT 980 988 17.
 REPEAT 989 997 18.
 REPEAT 998 1006 19.
 REPEAT 1007 1015 20.
 REPEAT 1036 1044 21.
 REPEAT 1045 1053 22.
 REPEAT 1054 1062 23.
 REPEAT 1072 1080 24.
 REPEAT 1081 1087 25.
 REGION 818 1087 25 X 9 AA approximate tandem repeats.
 MOD_RES 182 182 Phosphoserine.
 MOD_RES 183 183 Phosphoserine.
 MOD_RES 220 220 Phosphothreonine.
 MOD_RES 254 254 Phosphoserine.
 MOD_RES 274 274 Phosphoserine.
 MOD_RES 301 301 Phosphoserine.
 MOD_RES 585 585 Phosphoserine.
 MOD_RES 599 599 Phosphoserine.
 MOD_RES 646 646 Phosphoserine.
 MOD_RES 817 817 Phosphoserine.
 MOD_RES 820 820 Phosphoserine.
 MOD_RES 865 865 Phosphoserine.
 MOD_RES 883 883 Phosphoserine.
 MOD_RES 910 910 Phosphoserine.
 MOD_RES 937 937 Phosphoserine.
 MOD_RES 961 961 Phosphoserine.
 MOD_RES 979 979 Phosphoserine.
 MOD_RES 1056 1056 Phosphoserine.
 MOD_RES 1080 1080 Phosphoserine.
 MOD_RES 1173 1173 Phosphoserine.
 MOD_RES 1179 1179 Phosphothreonine.
 MOD_RES 1180 1180 Phosphoserine.
 MOD_RES 1251 1251 Phosphothreonine.
 MOD_RES 1263 1263 Phosphoserine.  

Keyword

 Cell shape; Coiled coil; Complete proteome; Phosphoprotein; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 1466 AA 

Protein Sequence

Gene Ontology

 GO:0051286; C:cell tip; IEA:UniProtKB-SubCell.
 GO:0005935; C:cellular bud neck; IDA:SGD.
 GO:0005934; C:cellular bud tip; IDA:SGD.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0043332; C:mating projection tip; IDA:SGD.
 GO:0000133; C:polarisome; IDA:SGD.
 GO:0005519; F:cytoskeletal regulatory protein binding; TAS:SGD.
 GO:0036267; P:invasive filamentous growth; IGI:SGD.
 GO:0031382; P:mating projection assembly; IGI:SGD.
 GO:0007124; P:pseudohyphal growth; IMP:SGD.
 GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
 GO:0031384; P:regulation of initiation of mating projection growth; IMP:SGD.
 GO:0031385; P:regulation of termination of mating projection growth; IMP:SGD. 

Interpro

 IPR013724; GIT_SHD. 

Pfam

 PF08518; GIT_SHD 

SMART

 SM00555; GIT 

PROSITE

  

PRINTS