CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032804
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Microtubule-associated protein 
Protein Synonyms/Alias
  
Gene Name
 MAP4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56PLLDVDEKTGNSESKacetylation[1]
56PLLDVDEKTGNSESKubiquitination[2]
254TTDMAPSKETEMALAacetylation[1]
276KTEVALAKDMESPTKacetylation[1]
312DMELPTEKEVALVKDubiquitination[2]
Reference
 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Microtubule; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 811 AA 
Protein Sequence
MADLSLADAL TEPSPDIEGE IKRDFIATLE AEAFDDVVGE TVGKTDYIPL LDVDEKTGNS 60
ESKKKPCSET SQIEDTPSSK PTLLANGGHG VEGSDTTGSP TEFLEEKMAY QEYPNSQNWP 120
EDTNFCFQPE QVVDPIQTDP FKMYHDDDLA DLVFPSSATA DTSIFAGQND PLKDSYGMSP 180
CNTAVVPQGW SVEALNSPHS ESFVSPEAVA EPPQPTAVPL ELAKEIEMAS EERPPAQALE 240
IMMGLKTTDM APSKETEMAL AKDMALATKT EVALAKDMES PTKLDVTLAK DMQPSMESDM 300
ALVKDMELPT EKEVALVKDG VRLPEPKDKI LETPQKMTEK SESKTPGEGK KEDKSRMAEP 360
MKGYMRPTKS RGLTPLLPKS TIQEQERHKQ LKSAGIARPE EGRPVVSGTG NDITTPPNKE 420
LPPSPEKKTK PLATTQPAKT STSKAKTQPT SLPKQPAPTT IGGLNKKPMS LASGLVPAAP 480
PKRPAVASAR PSILPSKDVK PKPIADAKAP EKRASPSKPA SAPASRSGSK STQTVAKTTT 540
AAAVASTGPS SRSPSTLLPK KPTAIKTEGK PAEVKKMTAK SVPADLSRPK STSTSSMKKT 600
TTLSGTAPAA GVVPSRVKAT PMPSRPSTTP FIDKKPTSAK PSSTTPRLSR LATNTSAPDL 660
KNVRSKVGST ENIKHQPGGG RVQIQNKKVD ISKVSSKCGS KANIKHKPGG GDVKIESQKL 720
NFKEKAQAKV GSLDNVGHLP AGGAVKTEGG GSEAPLCPGP PAGEEPAISE AAPEAGAPTS 780
ASGLNGHPTL SGGGDQREAQ TLDSQIQETS I 811 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0015630; C:microtubule cytoskeleton; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA. 
Interpro
 IPR027324; MAP2/MAP4/Tau.
 IPR027323; MAP4.
 IPR001084; Tau/MAP_tubulin-bd_rpt. 
Pfam
 PF00418; Tubulin-binding 
SMART
  
PROSITE
 PS00229; TAU_MAP_1
 PS51491; TAU_MAP_2 
PRINTS