UniProt Accession

 PCL1_YEAST; P24867; D6W0Q4 

Genbank Protein ID

 M73966; Z71565; BK006947 

Genbank Nucleotide ID

 AAA34617.1; CAA96206.1; DAA10270.1 

Protein Name

 PHO85 cyclin-1 

Protein Synonyms/Alias

 Cyclin HCS26; G1/S-specific cyclin PCL1 

Gene Name

 PCL1 

Gene Synonyms/Alias

 HCS26; YNL289W; N0536 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
47	PPGSPGEKHLTRLPS	ubiquitination	[1]
237	CNDLRRLKDVTNIAN	ubiquitination	[1]
258	NYVRTVEKWNDNVNR	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 G1/S-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. Essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 phosphorylates LCB4, which is required for its ubiquitination and degradation. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. 

Sequence Annotation

 DOMAIN 19 152 Cyclin N-terminal.  

Keyword

 Cell cycle; Cell division; Complete proteome; Cyclin; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IPI:SGD.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000131; C:incipient cellular bud site; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IDA:SGD.
 GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
 GO:0051301; P:cell division; IEA:UniProtKB-KW.
 GO:0016239; P:positive regulation of macroautophagy; IMP:SGD.
 GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:SGD.
 GO:0032878; P:regulation of establishment or maintenance of cell polarity; IGI:SGD.
 GO:0031106; P:septin ring organization; IGI:SGD. 

Interpro

 IPR013763; Cyclin-like.
 IPR006671; Cyclin_N.
 IPR012104; Cyclin_Pcl_fun. 

Pfam

 PF00134; Cyclin_N 

SMART

 SM00385; CYCLIN 

PROSITE

 PS00292; CYCLINS 

PRINTS