CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030986
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ribosomal protein S6 kinase beta-1 
Protein Synonyms/Alias
 cDNA FLJ53847, highly similar to Ribosomal protein S6 kinase beta-1 (EC 2.7.11.1) 
Gene Name
 RPS6KB1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
46ELLRVLGKGGYGKVFubiquitination[1]
51LGKGGYGKVFQVRKVubiquitination[1]
251NRKKTIDKILKCKLNacetylation[2]
397RTPVSPVKFSPGDFWubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Ribonucleoprotein; Ribosomal protein; Serine/threonine-protein kinase; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 472 AA 
Protein Sequence
MDHGGVGPYE LGMEHCEKFE ISETSVNRGP EKIRPECFEL LRVLGKGGYG KVFQVRKVTG 60
ANTGKIFAMK VLKKAMIVRN AKDTAHTKAE RNILEEVKHP FIVDLIYAFQ TGGKLYLILE 120
YLSGGELFMQ LEREGIFMED TACFYLAEIS MALGHLHQKG IIYRDLKPEN IMLNHQGHVK 180
LTDFGLCKES IHDGTVTHTF CGTIEYMAPE ILMRSGHNRA VDWWSLGALM YDMLTGAPPF 240
TGENRKKTID KILKCKLNLP PYLTQEARDL LKKLLKRNAA SRLGAGPGDA GEVQAHPFFR 300
HINWEELLAR KVEPPFKPLL QSEEDVSQFD SKFTRQTPVD SPDDSTLSES ANQVFLGFTY 360
VAPSVLESVK EKFSFEPKIR SPRRFIGSPR TPVSPVKFSP GDFWGRGASA STANPQTPVE 420
YPMETSGIEQ MDVTMSGEAS APLPIRQPNS GPYKKQAFPM ISKRPEHLRM NL 472 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005840; C:ribosome; IEA:UniProtKB-KW.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0042277; F:peptide binding; IEA:Compara.
 GO:0004711; F:ribosomal protein S6 kinase activity; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0016477; P:cell migration; IEA:Compara.
 GO:0032870; P:cellular response to hormone stimulus; IEA:Compara.
 GO:0007281; P:germ cell development; IEA:Compara.
 GO:0007616; P:long-term memory; IEA:Compara.
 GO:0046627; P:negative regulation of insulin receptor signaling pathway; IEA:Compara.
 GO:0048633; P:positive regulation of skeletal muscle tissue growth; IEA:Compara.
 GO:0014911; P:positive regulation of smooth muscle cell migration; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0043491; P:protein kinase B signaling cascade; IEA:Compara.
 GO:0046324; P:regulation of glucose import; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0014878; P:response to electrical stimulus involved in regulation of muscle adaptation; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0033762; P:response to glucagon stimulus; IEA:Compara.
 GO:0051384; P:response to glucocorticoid stimulus; IEA:Compara.
 GO:0009749; P:response to glucose stimulus; IEA:Compara.
 GO:0009408; P:response to heat; IEA:Compara.
 GO:0032868; P:response to insulin stimulus; IEA:Compara.
 GO:0043201; P:response to leucine; IEA:Compara.
 GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
 GO:0009612; P:response to mechanical stimulus; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:Compara.
 GO:0034612; P:response to tumor necrosis factor; IEA:Compara.
 GO:0009611; P:response to wounding; IEA:Compara.
 GO:0014732; P:skeletal muscle atrophy; IEA:Compara.
 GO:0003009; P:skeletal muscle contraction; IEA:Compara. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR017892; Pkinase_C.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR016238; Ribosomal_S6_kinase.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C 
SMART
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS