CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032152
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 DNA-directed RNA polymerase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
55LPSGPSLKHLTDPSYubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 DNA-directed RNA polymerase; Nucleotidyltransferase; Transcription; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1173 AA 
Protein Sequence
MRAKEAAETG LRPLLPACTE RLASGVYRET GVRCAGGHMD PGSRWRNLPS GPSLKHLTDP 60
SYGIPREQQK AALQELTRAH VESFNYAVHE GLGLAVQAIP PFEFAFKDER ISFTILDAVI 120
SPPTVPKGTI CKEANVYPAE CRGRRSTYRG KLTADINWAV NGISKGIIKQ FLGYVPIMVK 180
SKLCNLRNLP PQALIEHHEE AEEMGGYFII NGIEKVIRML IMPRRNFPIA MIRPKWKTRG 240
PGYTQYGVSM HCVREEHSAV NMNLHYLENG TVMLNFIYRK ELFFLPLGFA LKALVSFSDY 300
QIFQELIKGK EDDSFLRNSV SQMLRIVMEE GCSTQKQVLN YLGECFRVKL NVPDWYPNEQ 360
AAEFLFNQCI CIHLKSNTEK FYMLCLMTRK LFALAKGECM EDNPDSLVNQ EVLTPGQLFL 420
MFLKEKLEGW LVSIKIAFDK KAQKTSVSMN TDNLMRIFTM GIDLTKPFEY LFATGNLRSK 480
TGLGLLQDSG LCVVADKLNF IRYLSHFRCV HRGADFAKMR TTTVRRLLPE SWGFLCPVHT 540
PDGEPCGLMN HLTAVCEVVT QFVYTASIPA LLCNLGVTPI DGAPHRSYSE CYPVLLDGVM 600
VGWVDKDLAP GIADSLRHFK VLREKRIPPW MEVVLIPMTG KPSLYPGLFL FTTPCRLVRP 660
VQNLALGKEE LIGTMEQIFM NVAIFEDEVF AGVTTHQELF PHSLLSVIAN FIPFSDHNQS 720
PRNMYQCQMG KQTMGFPLLT YQDRSDNKLY RLQTPQSPLV RPSMYDYYDM DNYPIGTNAI 780
VAVISYTGYD MEDAMIVNKA SWERGFAHGS VYKSEFIDLS EKIKQGDSSL VFGIKPGDPR 840
VLQKLDDDGL PFIGAKLQYG DPYYSYLNLN TGESFVMYYK SKENCVVDNI KVCSNDTGSG 900
KFKCVCITMR VPRNPTIGDK FASRHGQKGI LSRLWPAEDM PFTESGMVPD ILFNPHGFPS 960
RMTIGMLIES MAGKSAALHG LCHDATPFIF SEENSALEYF GEMLKAAGYN FYGTERLYSG 1020
ISGLELEADI FIGVVYYQRL RHMVSDKFQV RTTGARDRVT NQPIGGRNVQ GGIRFGGMER 1080
DALLAHGTSF LLHDRLFNCS DRSVAHVCVK CGSLLSPLLE KPPPSWSAMR NRKYNCTLCS 1140
RSDTIDTVSV PYVFRYFVAE LAAMNIKVKL DVV 1173 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
 GO:0032549; F:ribonucleoside binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR015712; DNA-dir_RNA_pol_su2.
 IPR007120; DNA-dir_RNA_pol_su2_6.
 IPR007121; RNA_pol_bsu_CS.
 IPR007644; RNA_pol_bsu_protrusion.
 IPR009674; RNA_pol_Rpa2-specific.
 IPR007642; RNA_pol_Rpb2_2.
 IPR007645; RNA_pol_Rpb2_3.
 IPR007647; RNA_pol_Rpb2_5.
 IPR007641; RNA_pol_Rpb2_7.
 IPR014724; RNA_pol_RPB2_OB-fold. 
Pfam
 PF06883; RNA_pol_Rpa2_4
 PF04563; RNA_pol_Rpb2_1
 PF04561; RNA_pol_Rpb2_2
 PF04565; RNA_pol_Rpb2_3
 PF04567; RNA_pol_Rpb2_5
 PF00562; RNA_pol_Rpb2_6
 PF04560; RNA_pol_Rpb2_7 
SMART
  
PROSITE
 PS01166; RNA_POL_BETA 
PRINTS