| Tag | Content |
|---|
| CPLM ID | CPLM-002882 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Acetyl-/propionyl-coenzyme A carboxylase alpha chain |
Protein Synonyms/Alias | Biotin carboxylase; Biotin carboxyl carrier protein; BCCP |
Gene Name | accA1 |
Gene Synonyms/Alias | bccA; Rv2501c; MT2576; MTCY07A7.07c |
Created Date | July 27, 2013 |
Organism | Mycobacterium tuberculosis |
NCBI Taxa ID | 1773 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 322 | LRVGAGEKLGFAQND | pupylation | [1] |
|
Reference | [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] . Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH. PLoS One. 2010 Jan 6;5(1):e8589. [ PMID: 20066036] |
Functional Description | This protein carries two functions: biotin carboxyl carrier protein and biotin carboxyltransferase (By similarity). |
Sequence Annotation | DOMAIN 1 448 Biotin carboxylation.
DOMAIN 120 319 ATP-grasp.
DOMAIN 586 652 Biotinyl-binding.
ACT_SITE 294 294 By similarity.
BINDING 116 116 ATP (By similarity).
BINDING 200 200 ATP (By similarity).
BINDING 235 235 ATP (By similarity).
MOD_RES 620 620 N6-biotinyllysine (By similarity).
CROSSLNK 322 322 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | ATP-binding; Biotin; Complete proteome; Fatty acid biosynthesis; Fatty acid metabolism; Isopeptide bond; Ligase; Lipid biosynthesis; Lipid metabolism; Multifunctional enzyme; Nucleotide-binding; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 654 AA |
Protein Sequence | MFDTVLVANR GEIAVRVIRT LRRLGIRSVA VYSDPDVDAR HVLEADAAVR LGPAPARESY 60
LDIGKVLDAA ARTGAQAIHP GYGFLAENAD FAAACERARV VFLGPPARAI EVMGDKIAAK 120
NAVAAFDVPV VPGVARAGLT DDALVTAAAE VGYPVLIKPS AGGGGKGMRL VQDPARLPEA 180
LVSARREAMS SFGDDTLFLE RFVLRPRHIE VQVLADAHGN VVHLGERECS LQRRHQKVIE 240
EAPSPLLDPQ TRERIGVAAC NTARCVDYVG AGTVEFIVSA QRPDEFFFME MNTRLQVEHP 300
VTEAITGLDL VEWQLRVGAG EKLGFAQNDI ELRGHAIEAR VYAEDPAREF LPTGGRVLAV 360
FEPAGPGVRV DSSLLGGTVV GSDYDPLLTK VIAHGADREE ALDRLDQALA RTAVLGVQTN 420
VEFLRFLLAD ERVRVGDLDT AVLDERSADF TARPAPDDVL AAGGLYRQWA LARRAQGDLW 480
AAPSGWRGGG HMAPVRTAMR TPLRSETVSV WGPPESAQVQ VGDGEIDCAS VQVTREQMSV 540
TISGLRRDYR WAEADRHLWI ADERGTWHLR EAEEHKIHRA VGARPAEVVS PMPGSVIAVQ 600
VESGSQISAG DVVVVVEAMK MEHSLEAPVS GRVQVLVSVG DQVKVEQVLA RIKD 654 |
Gene Ontology | GO:0005886; C:plasma membrane; IDA:MTBBASE. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004075; F:biotin carboxylase activity; IEA:EC. GO:0046872; F:metal ion binding; IEA:InterPro. GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |