CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002413
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Porphobilinogen deaminase 
Protein Synonyms/Alias
 PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase 
Gene Name
 hemC 
Gene Synonyms/Alias
 popE; b3805; JW5932 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
24LWQAHYVKDKLMASHacetylation[1]
64GGKGLFVKELEVALLacetylation[1]
158NVGTRLSKLDNGEYDacetylation[1]
175ILAVAGLKRLGLESRacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. 
Sequence Annotation
 MOD_RES 242 242 S-(dipyrrolylmethanemethyl)cysteine.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Porphyrin biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 313 AA 
Protein Sequence
MLDNVLRIAT RQSPLALWQA HYVKDKLMAS HPGLVVELVP MVTRGDVILD TPLAKVGGKG 60
LFVKELEVAL LENRADIAVH SMKDVPVEFP QGLGLVTICE REDPRDAFVS NNYDSLDALP 120
AGSIVGTSSL RRQCQLAERR PDLIIRSLRG NVGTRLSKLD NGEYDAIILA VAGLKRLGLE 180
SRIRAALPPE ISLPAVGQGA VGIECRLDDS RTRELLAALN HHETALRVTA ERAMNTRLEG 240
GCQVPIGSYA ELIDGEIWLR ALVGAPDGSQ IIRGERRGAP QDAEQMGISL AEELLNNGAR 300
EILAEVYNGD APA 313 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:EcoliWiki.
 GO:0004418; F:hydroxymethylbilane synthase activity; IMP:EcoliWiki.
 GO:0015995; P:chlorophyll biosynthetic process; IEA:HAMAP.
 GO:0006783; P:heme biosynthetic process; IMP:EcoliWiki.
 GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IDA:EcoliWiki.
 GO:0006782; P:protoporphyrinogen IX biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR000860; 4pyrrol_synth_OHMeBilane_synth.
 IPR022419; Porphobilin_deaminase_cofac_BS.
 IPR022417; Porphobilin_deaminase_N.
 IPR022418; Porphobilinogen_deaminase_C. 
Pfam
 PF01379; Porphobil_deam
 PF03900; Porphobil_deamC 
SMART
  
PROSITE
 PS00533; PORPHOBILINOGEN_DEAM 
PRINTS
 PR00151; PORPHBDMNASE.