UniProt Accession

 CO16A_CONGE; P01522 

Genbank Protein ID

 M84612 

Genbank Nucleotide ID

 AAA81590.1 

Protein Name

 Omega-conotoxin GVIA 

Protein Synonyms/Alias

 SNX-124; Shaker peptide; Omega-conotoxin GVIB; Omega-conotoxin GVIC 

Gene Name

  

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Conus geographus (Geography cone) (Nubecula geographus) 

NCBI Taxa ID

 6491 

Lysine Modification

Position	Peptide	Type	References
47	LSLSTRCKSPGSSCS	acetylation	[1]
69	RSCNPYTKRCYG***	acetylation	[1]

Reference

 [1] Effects of site-specific acetylation on omega-conotoxin GVIA binding and function.
 Lampe RA, Lo MM, Keith RA, Horn MB, McLane MW, Herman JL, Spreen RC.
 Biochemistry. 1993 Apr 6;32(13):3255-60. [PMID: 8461292] 

Functional Description

 Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). 

Sequence Annotation

 MOD_RES 49 49 4-hydroxyproline.
 MOD_RES 55 55 4-hydroxyproline.
 MOD_RES 66 66 4-hydroxyproline.
 MOD_RES 72 72 Tyrosine amide; in form omega-conotoxin
 DISULFID 46 61
 DISULFID 53 64
 DISULFID 60 71  

Keyword

 3D-structure; Amidation; Calcium channel inhibitor; Direct protein sequencing; Disulfide bond; Hydroxylation; Ion channel impairing toxin; Knottin; Neurotoxin; Presynaptic neurotoxin; Secreted; Signal; Toxin. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 73 AA 

Protein Sequence

Gene Ontology

 GO:0072556; C:other organism presynaptic membrane; IEA:UniProtKB-KW.
 GO:0019855; F:calcium channel inhibitor activity; IEA:UniProtKB-KW.
 GO:0009405; P:pathogenesis; IEA:InterPro. 

Interpro

 IPR004214; Conotoxin.
 IPR012321; Conotoxin_omega-typ_CS. 

Pfam

 PF02950; Conotoxin 

SMART

  

PROSITE

 PS60004; OMEGA_CONOTOXIN 

PRINTS