CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038433
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein Akap13 
Protein Synonyms/Alias
  
Gene Name
 Akap13 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
135DVNSLDEKVALAFRHubiquitination[1]
286NIQQQLMKTNLKQMDubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2794 AA 
Protein Sequence
MKLSPQQAPL YGDCVVTVLL AEEDKVEDDA IFYLIFSGST LYHCTSTRKV SSDTLETIAP 60
GHDCCETVKV LLCASREGLP VFVVAEEDFH FVQDEAYDAA QFLATSAGNQ QALNFTRFLD 120
RSGPPSRDVN SLDEKVALAF RHLKLPAEWN VLGTDHTLHD GGPRETLMHF AVRLGLLRLT 180
WFLLQKPGGR GALSIHNKEG ATPVSLALER GYHELHQLLT EENAGEPDSW SSLSYEIPYG 240
DCSVRHHREL DIYTLTSESE SHREPHGDSC TGHISKLMNI QQQLMKTNLK QMDNLMPLMV 300
TAQDSSCVPS VPETDGLFLP CVPEPSDHQH PPFEETKSTL CCQRSPGRMA ESSCDLSSMV 360
EEENVICSHK KNKDVGRKGE EAEPASAMDS GSASHQDSCL QSVPDCGVKG REGLPSCGNR 420
NEVTGTNYSG VATCQQPLSS RSSVLQDAMV TEPDACQHSS GRELPDSSST DVGAPEKAGE 480
LEHSLLTPDA TTQNNKPQVG EGTKERLENS DSSTTETTAV QVLSEPMEKA DITNHVFATS 540
AVGVNTPAEA SPALSSEEIP TEKPGMETQE RGCEGGTTSD QSSPVLPAAA IENKVLGGQE 600
PDTSIAGFCK TASPLDLTMP GPSSDGMPEQ NSESHARPAQ SLSGQALLCS TAEAGTPSAE 660
ATHQPSTVTS SGRLEECGSG KASLPESTMV QPSTQELCTT LCPEDPQADT VTSDTVKNTQ 720
KSVGVCHLCV SDAKNQGNGL KQDTPLTNVL EDVPRLPSVV SQTEKELAPD QVSPPASSFS 780
LASSPESESV TKDDALSLVP SQKEKGTATP QLHRTTACRD GPDGRDLSDT DKVGDGATDP 840
PPSSAVELRT SMGNTSPVGI GGEQEGSSPT ATLEVLSDSL LHNVDKAALV SDFTLPEEGV 900
SVVVPESSTA LGQDGKDRAM SCSSVKEDVH SSEMSREDQR TPPSGQEIPG LCEKPMSALC 960
AEEKAQQHTP SACLKTETKD IKEVAPQVSL LTEGGAAKSL VPPRTSLSAD SKQKASSTEQ 1020
SGSSLLPSGL PGASEALHCN QPSALDVVVE NTQFQGETNA CEVSRSAMED VTVADASPAT 1080
AEPRKKDASH CIKDIPISEL LNQEKQMTPS LPEAFLDKGV TDLQEVITPE IEPLDCKRET 1140
LEGTDLNCAT SNSKETPIEK PMQPLARDLP TETGLSVINN NVPQADMKQV AQASIPAEES 1200
NATTVSTQAA DVPTRADSIE ETATRIVEAV IRQVRASNAL MAKVETQNPS LSSPETKQLE 1260
NAYTESACAF LPGETPQIEK THEDTTGQCG AETEEPEKII LPESAPEMPD TRTGDEVDLL 1320
SRISAASEEE AVGNGAATPK MKQGPGTQAI NRESWCAIEP CPEAASLLAS KQSSECRSFI 1380
DVGLGTECAS KEGMLQRVSG SESDLFHSPS DEMDSIIFPK PEEEQLLCDT TGSSSSTDDT 1440
ASLDRHSSHG SDVSLPQTSK LNRSRNHQSA NGFFSPGVEA PESRESESEP AGSGEMEEEE 1500
MDSITEVPAN CSFLRSSMRS LSPFRRHSWG PGKNAASDAE MNQRSSMRAL GHVVRRPPIH 1560
RRSMSWCPSG VQYSAALNAD FNIRSFSLEG LTGGGVGNKP SSSLEMSSAN SSELRNPFGG 1620
EEQRNSLMSL SEEHLEPDQR QHHRMFDQQT CYRSKQQGFN YCTSAISSPL TKSISLMTIS 1680
HPGLDSSRPF HSTSANLTES ITEENCNFLP PSPSKKNFEE KSGTKVSRTF SYIRNKMSSS 1740
KKSKEKEKEK DKIKEKEKDS KEKEKDKKTL NGHTFSPIPI VGPISCSQCM KPFTNKDAYT 1800
CAGCGAFVHK GCRENLASCA KVKMKQPKGS LQAHDTSSLP TVIMRNKSSQ PKERPRSAVL 1860
LADEATAAPM FTNRRSQQSV SLSKSVSIQN ITGVGNDENM SNTWKFLSHS TDSLNKICKV 1920
NESTESLTDE GVGTDMNEGQ LMGDFESDSK QLEAESWSRT VDSKFLKQQK KDVVKRQEVI 1980
YELMQTELHH IRTLKIMSDV YSRGMMTDLL FEQQMVEKLF PCLDELISIH SQFFQRILER 2040
KKESLVDKSE KNFLIKRIGD VLVSQFSGES AERLKKTYGK FCGQHNQSVN YFKDLYTKDK 2100
RFQAFVKKKM SSSVVRRLGI PECILLVTQR ITKYPVLFQR ILQCTKDNEV EQEDLTQSLS 2160
LVKDVIGAVD SKVASYEKKV RLGEIYTKTD SKSIMRMKSG QMFAKEDLRR KKLVRDGSVF 2220
LKSTTGRLKE VQAVLLTDIL VFLQEKDQKY VFASLDHKST VISLKKLIVR EVAHEEKGLF 2280
LISMGVKDPE MVEVHASSRE ERNSWIQIIQ DTINSLNRDE DEGIPSENEE EKKLLDTKAR 2340
ELKEQLQQKD QQILLLLEEK EMIFRDMTEC STPLPEDCSP THSPRVLFRS NTEEALKGGP 2400
LMKSAINEVE ILQSLVSGSL GGTLGQSISS PVEQEVMAAP ISLPRRAETF GGFDCHQMNA 2460
SKGGEKEEGD DGQDLRRTES DSGLKKGGNG NLVFMLKRNS EQVVQSIVHL HELLSMLQGV 2520
VLQQDSYIED QKLVLTEKVL TRSASRPSSL IEQEKQRSLE KQRQDLANLQ KQQAQHLEEK 2580
RRREREWEAR EQELRDREAK LAEREETVRR RQQDLERDRE ELQQKKGTYQ CDLERLRAAQ 2640
KQLEREQEQL RRDTERLSQR QMDQNLCQVS NKHGRLMRIP SFLPNSDEFS SPSAPSVTKS 2700
GSLDSELSVS PKRNSISRTQ KDKGPFHILG SASQTKVPEG QSQAPSSTST STRLFGLSKP 2760
KEKKEKKKKS KGSRTQPGDG PASEVPAEGE EIFC 2794 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:1900169; P:regulation of glucocorticoid mediated signaling pathway; IMP:MGI.
 GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. 
Interpro
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000219; DH-domain.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR015721; RhoGEF-like. 
Pfam
 PF00169; PH
 PF00621; RhoGEF 
SMART
 SM00109; C1
 SM00233; PH
 SM00325; RhoGEF 
PROSITE
 PS50010; DH_2
 PS50003; PH_DOMAIN
 PS00479; ZF_DAG_PE_1
 PS50081; ZF_DAG_PE_2 
PRINTS