| Tag | Content |
|---|
| CPLM ID | CPLM-019655 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | CDK5 regulatory subunit-associated protein 1 |
Protein Synonyms/Alias | CDK5 activator-binding protein C42 |
Gene Name | CDK5RAP1 |
Gene Synonyms/Alias | C20orf34; CGI-05; HSPC167 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 70 | PTFQHFLKSASAPQE | ubiquitination | [1] | | 78 | SASAPQEKLSSEVED | ubiquitination | [1] | | 189 | GCMAERLKEEILNRE | ubiquitination | [1, 2] | | 197 | EEILNREKMVDILAG | ubiquitination | [2] | | 287 | ASILEEVKKLSEQGL | ubiquitination | [1] | | 288 | SILEEVKKLSEQGLK | ubiquitination | [2] | | 295 | KLSEQGLKEVTLLGQ | ubiquitination | [1, 2] | | 332 | RGFTTNYKTKQGGLR | ubiquitination | [2] | | 382 | HERDNICKQIHLPAQ | ubiquitination | [2] | | 473 | TRAYHRLKDDVPEEV | ubiquitination | [1, 2] | | 481 | DDVPEEVKLRRLEEL | ubiquitination | [1, 2] | | 517 | VLVEGLSKRSATDLC | ubiquitination | [2] | | 532 | GRNDGNLKVIFPDAE | ubiquitination | [1, 2] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Specifically inhibits CDK5 activation by CDK5R1. |
Sequence Annotation | DOMAIN 100 220 MTTase N-terminal.
DOMAIN 515 590 TRAM.
REGION 22 157 CDK5 activation inhibition.
REGION 475 586 CDK5R1-binding.
METAL 109 109 Iron-sulfur (4Fe-4S) (By similarity).
METAL 145 145 Iron-sulfur (4Fe-4S) (By similarity).
METAL 183 183 Iron-sulfur (4Fe-4S) (By similarity).
METAL 258 258 Iron-sulfur (4Fe-4S-S-AdoMet) (By
METAL 262 262 Iron-sulfur (4Fe-4S-S-AdoMet) (By
METAL 265 265 Iron-sulfur (4Fe-4S-S-AdoMet) (By |
Keyword | 4Fe-4S; Alternative splicing; Complete proteome; Iron; Iron-sulfur; Metal-binding; Reference proteome; S-adenosyl-L-methionine. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 601 AA |
Protein Sequence | MHPLQCVLQV QRSLGWGPLA SVSWLSLRMC RAHSSLSSTM CPSPERQEDG ARKDFSSRLA 60
AGPTFQHFLK SASAPQEKLS SEVEDPPPYL MMDELLGRQR KVYLETYGCQ MNVNDTEIAW 120
SILQKSGYLR TSNLQEADVI LLVTCSIREK AEQTIWNRLH QLKALKTRRP RSRVPLRIGI 180
LGCMAERLKE EILNREKMVD ILAGPDAYRD LPRLLAVAES GQQAANVLLS LDETYADVMP 240
VQTSASATSA FVSIMRGCDN MCSYCIVPFT RGRERSRPIA SILEEVKKLS EQGLKEVTLL 300
GQNVNSFRDN SEVQFNSAVP TNLSRGFTTN YKTKQGGLRF AHLLDQVSRV DPEMRIRFTS 360
PHPKDFPDEV LQLIHERDNI CKQIHLPAQS GSSRVLEAMR RGYSREAYVE LVHHIRESIP 420
GVSLSSDFIA GFCGETEEDH VQTVSLLREV QYNMGFLFAY SMRQKTRAYH RLKDDVPEEV 480
KLRRLEELIT IFREEATKAN QTSVGCTQLV LVEGLSKRSA TDLCGRNDGN LKVIFPDAEM 540
EDVNNPGLRV RAQPGDYVLV KITSASSQTL RGHVLCRTTL RDSSAYC 587 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:InterPro. GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019901; F:protein kinase binding; NAS:UniProtKB. GO:0016740; F:transferase activity; IEA:InterPro. GO:0007420; P:brain development; NAS:UniProtKB. GO:0045736; P:negative regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:UniProtKB. GO:0045664; P:regulation of neuron differentiation; NAS:UniProtKB. GO:0006400; P:tRNA modification; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |