UniProt Accession

 PLEK_HUMAN; P08567; B2R9E8; Q53SU8; Q6FGM8; Q6FGQ1; Q8WV81 

Genbank Protein ID

 X07743; CR542056; CR542079; AK313756; AC015969; CH471053; BC018549 

Genbank Nucleotide ID

 CAA30564.1; CAG46853.1; CAG46876.1; BAG36495.1; AAX93121.1; EAW99876.1; AAH18549.1 

Protein Name

 Pleckstrin 

Protein Synonyms/Alias

 Platelet 47 kDa protein; p47 

Gene Name

 PLEK 

Gene Synonyms/Alias

 P47 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
64	SPCQDFGKRMFVFKI	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Major protein kinase C substrate of platelets. 

Sequence Annotation

 DOMAIN 4 101 PH 1.
 DOMAIN 136 221 DEP.
 DOMAIN 244 347 PH 2.
 MOD_RES 64 64 N6-acetyllysine.
 MOD_RES 113 113 Phosphoserine; by PKC.
 MOD_RES 117 117 Phosphoserine; by PKC.  

Keyword

 3D-structure; Acetylation; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 350 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0032587; C:ruffle membrane; IDA:BHF-UCL.
 GO:0043325; F:phosphatidylinositol-3,4-bisphosphate binding; IDA:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
 GO:0005080; F:protein kinase C binding; IDA:BHF-UCL.
 GO:0031532; P:actin cytoskeleton reorganization; IDA:BHF-UCL.
 GO:0030866; P:cortical actin cytoskeleton organization; IDA:BHF-UCL.
 GO:0002244; P:hematopoietic progenitor cell differentiation; IEP:BHF-UCL.
 GO:0007229; P:integrin-mediated signaling pathway; IDA:BHF-UCL.
 GO:0050849; P:negative regulation of calcium-mediated signaling; NAS:BHF-UCL.
 GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IDA:BHF-UCL.
 GO:0010920; P:negative regulation of inositol phosphate biosynthetic process; IDA:BHF-UCL.
 GO:0046488; P:phosphatidylinositol metabolic process; IDA:BHF-UCL.
 GO:0030845; P:phospholipase C-inhibiting G-protein coupled receptor signaling pathway; IDA:BHF-UCL.
 GO:0070527; P:platelet aggregation; ISS:BHF-UCL.
 GO:0032233; P:positive regulation of actin filament bundle assembly; IDA:BHF-UCL.
 GO:0030836; P:positive regulation of actin filament depolymerization; IDA:BHF-UCL.
 GO:0010925; P:positive regulation of inositol-polyphosphate 5-phosphatase activity; IDA:BHF-UCL.
 GO:0033625; P:positive regulation of integrin activation; ISS:BHF-UCL.
 GO:0010572; P:positive regulation of platelet activation; ISS:BHF-UCL.
 GO:0070528; P:protein kinase C signaling cascade; ISS:BHF-UCL.
 GO:0070560; P:protein secretion by platelet; ISS:BHF-UCL.
 GO:0060305; P:regulation of cell diameter; IDA:BHF-UCL.
 GO:0031529; P:ruffle organization; IDA:BHF-UCL.
 GO:0070493; P:thrombin receptor signaling pathway; IDA:BHF-UCL.
 GO:0006904; P:vesicle docking involved in exocytosis; ISS:BHF-UCL. 

Interpro

 IPR000591; DEP_dom.
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00610; DEP
 PF00169; PH 

SMART

 SM00049; DEP
 SM00233; PH 

PROSITE

 PS50186; DEP
 PS50003; PH_DOMAIN 

PRINTS