CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022359
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 
Protein Synonyms/Alias
 Alkylated DNA repair protein alkB homolog 4 
Gene Name
 ALKBH4 
Gene Synonyms/Alias
 ABH4 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98LMDRDPWKLSQSGRRubiquitination[1]
121NFRKQKLKTEGFCGLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity). 
Sequence Annotation
 METAL 169 169 Iron; catalytic (By similarity).
 METAL 171 171 Iron; catalytic (By similarity).
 METAL 254 254 Iron; catalytic (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Cytoplasm; Dioxygenase; Iron; Metal-binding; Nucleus; Oxidoreductase; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 302 AA 
Protein Sequence
MAAAAAETPE VLRECGCKGI RTCLICERQR GSDPPWELPP AKTYRFIYCS DTGWAVGTEE 60
SDFEGWAFPF PGVMLIEDFV TREEEAELVR LMDRDPWKLS QSGRRKQDYG PKVNFRKQKL 120
KTEGFCGLPS FSREVVRRMG LYPGLEGFRP VEQCNLDYCP ERGSAIDPHL DDAWLWGERL 180
VSLNLLSPTV LSMCREAPGS LLLCSAPSAA PEALVDSVIA PSRSVLCQEV EVAIPLPARS 240
LLVLTGAARH QWKHAIHRRH IEARRVCVTF RELSAEFGPG GRQQELGQEL LRIALSFQGR 300
PV 302 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0016706; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; IEA:InterPro.
 GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:UniProtKB-KW. 
Interpro
 IPR027450; AlkB-like.
 IPR005123; Oxoglu/Fe-dep_dioxygenase. 
Pfam
 PF03171; 2OG-FeII_Oxy 
SMART
  
PROSITE
  
PRINTS