| Tag | Content |
|---|
| CPLM ID | CPLM-008089 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tryptophan 2,3-dioxygenase |
Protein Synonyms/Alias | TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase |
Gene Name | Tdo2 |
Gene Synonyms/Alias | Tdo |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 16 | NSVGYTLKNVSMEDN | ubiquitination | [1] | | 37 | TGVNRASKGGLIYGN | ubiquitination | [1] | | 50 | GNYLQLEKILNAQEL | ubiquitination | [1] | | 62 | QELQSEVKGNKIHDE | ubiquitination | [1] | | 164 | QFRLLENKIGVLQSL | ubiquitination | [1] | | 225 | NGFNFWGKFEKNILK | ubiquitination | [1] | | 228 | NFWGKFEKNILKGLE | ubiquitination | [1] | | 232 | KFEKNILKGLEEEFL | ubiquitination | [1] | | 244 | EFLRIQAKTDSEEKE | ubiquitination | [1] | | 250 | AKTDSEEKEEQMAEF | ubiquitination | [1] | | 261 | MAEFRKQKEVLLCLF | ubiquitination | [1] | | 271 | LLCLFDEKRHDYLLS | ubiquitination | [1] | | 279 | RHDYLLSKGERRLSY | ubiquitination | [1] | | 339 | VHRMLGTKAGTGGSS | ubiquitination | [1] | | 380 | VPRHWVPKMNPIIHK | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). |
Sequence Annotation | REGION 42 46 Substrate binding (By similarity).
REGION 72 76 Substrate binding (By similarity).
METAL 328 328 Iron (heme axial ligand) (By similarity).
BINDING 144 144 Substrate (By similarity).
BINDING 151 151 Heme (By similarity).
BINDING 342 342 Substrate (By similarity).
MOD_RES 19 19 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; Dioxygenase; Heme; Iron; Metal-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Tryptophan catabolism. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 406 AA |
Protein Sequence | MSGCPFAGNS VGYTLKNVSM EDNEEDRAQT GVNRASKGGL IYGNYLQLEK ILNAQELQSE 60
VKGNKIHDEH LFIITHQAYE LWFKQILWEL DSVREIFQNG HVRDERNMLK VIARMHRVVV 120
IFKLLVQQFS VLETMTALDF NDFREYLSPA SGFQSLQFRL LENKIGVLQS LRVPYNRKHY 180
RDNFGGDYNE LLLKSEQEQT LLQLVEAWLE RTPGLEPNGF NFWGKFEKNI LKGLEEEFLR 240
IQAKTDSEEK EEQMAEFRKQ KEVLLCLFDE KRHDYLLSKG ERRLSYRALQ GALMIYFYRE 300
EPRFQVPFQL LTSLMDIDTL MTKWRYNHVC MVHRMLGTKA GTGGSSGYHY LRSTVSDRYK 360
VFVDLFNLST YLVPRHWVPK MNPIIHKFLY TAEYSDSSYF SSDESD 406 |
Gene Ontology | GO:0016597; F:amino acid binding; IEA:Compara. GO:0020037; F:heme binding; IBA:RefGenome. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0019825; F:oxygen binding; IEA:Compara. GO:0004833; F:tryptophan 2,3-dioxygenase activity; IBA:RefGenome. GO:0019442; P:tryptophan catabolic process to acetyl-CoA; IBA:RefGenome. GO:0019441; P:tryptophan catabolic process to kynurenine; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |