CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020118
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protease-associated domain-containing protein 1 
Protein Synonyms/Alias
 Protease-associated domain-containing protein of 21 kDa; hPAP21 
Gene Name
 PRADC1 
Gene Synonyms/Alias
 C2orf7; PAP21; UNQ833/PRO1760 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50IFTATPAKDFGGIFHubiquitination[1, 2, 3, 4]
100GGCSFLSKTRVVQEHubiquitination[2, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094
Functional Description
  
Sequence Annotation
 DOMAIN 83 163 PA.
 CARBOHYD 171 171 N-linked (GlcNAc...).  
Keyword
 Complete proteome; Glycoprotein; Reference proteome; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 188 AA 
Protein Sequence
MVPGAAGWCC LVLWLPACVA AHGFRIHDYL YFQVLSPGDI RYIFTATPAK DFGGIFHTRY 60
EQIHLVPAEP PEACGELSNG FFIQDQIALV ERGGCSFLSK TRVVQEHGGR AVIISDNAVD 120
NDSFYVEMIQ DSTQRTADIP ALFLLGRDGY MIRRSLEQHG LPWAIISIPV NVTSIPTFEL 180
LQPPWTFW 188 
Gene Ontology
 GO:0005576; C:extracellular region; IDA:UniProtKB. 
Interpro
 IPR003137; Protease-assoc_domain. 
Pfam
 PF02225; PA 
SMART
  
PROSITE
  
PRINTS