UniProt Accession

 E41L3_MOUSE; Q9WV92; Q69ZT8; Q9R102 

Genbank Protein ID

 AF152247; AF177146; AK173080 

Genbank Nucleotide ID

 AAD38048.1; AAD51365.1; BAD32358.1 

Protein Name

 Band 4.1-like protein 3 

Protein Synonyms/Alias

 4.1B; Differentially expressed in adenocarcinoma of the lung protein 1; DAL-1; DAL1P; mDAL-1; Band 4.1-like protein 3, N-terminally processed 

Gene Name

 Epb41l3 

Gene Synonyms/Alias

 Dal1; Epb4.1l3; Kiaa0987 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
94	YQQFEDDKLSQRSSS	ubiquitination	[1]
136	EYGCDVDKRSRGQVL	ubiquitination	[1]
146	RGQVLFDKVCEHLNL	acetylation	[2]
146	RGQVLFDKVCEHLNL	ubiquitination	[1]
156	EHLNLLEKDYFGLTY	ubiquitination	[1]
170	YRDAENQKNWLDPAK	ubiquitination	[1, 3]
269	RFAPNHTKELEDKVI	ubiquitination	[1]
274	HTKELEDKVIELHKS	acetylation	[4]
274	HTKELEDKVIELHKS	ubiquitination	[1, 3]
405	LLPEAPPKKFLTLGS	ubiquitination	[1]
498	ITTVTPEKKAEEERV	ubiquitination	[1]
578	QTNISELKRTFLETS	ubiquitination	[1]
630	TKQSSGEKLMDGSEI	ubiquitination	[1]
646	SLLESARKPTEFIGG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [3] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N- methyltransferases, including PRMT3 and PRMT5 (By similarity). 

Sequence Annotation

 DOMAIN 118 399 FERM.
 REGION 402 528 Hydrophilic.
 REGION 559 602 Spectrin--actin-binding.
 REGION 777 929 C-terminal (CTD).
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 2 2 N-acetylthreonine; in Band 4.1-like
 MOD_RES 96 96 Phosphoserine.
 MOD_RES 428 428 Phosphoserine.
 MOD_RES 451 451 Phosphoserine.
 MOD_RES 470 470 Phosphoserine.
 MOD_RES 486 486 Phosphoserine.
 MOD_RES 488 488 Phosphothreonine.
 MOD_RES 495 495 Phosphothreonine.
 MOD_RES 542 542 Phosphothreonine.
 MOD_RES 543 543 Phosphoserine.
 MOD_RES 547 547 Phosphoserine.
 MOD_RES 599 599 Phosphoserine.
 MOD_RES 623 623 Phosphothreonine.
 MOD_RES 626 626 Phosphoserine.
 MOD_RES 627 627 Phosphoserine.
 MOD_RES 797 797 Phosphoserine.
 MOD_RES 798 798 Phosphothreonine.
 MOD_RES 804 804 Phosphoserine.
 MOD_RES 923 923 Phosphothreonine.  

Keyword

 Acetylation; Actin-binding; Alternative splicing; Apoptosis; Cell junction; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Phosphoprotein; Reference proteome; Tumor suppressor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 929 AA 

Protein Sequence

Gene Ontology

 GO:0005911; C:cell-cell junction; ISS:HGNC.
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0019898; C:extrinsic to membrane; IEA:InterPro.
 GO:0044224; C:juxtaparanode region of axon; IDA:BHF-UCL.
 GO:0033270; C:paranode region of axon; IDA:BHF-UCL.
 GO:0005200; F:structural constituent of cytoskeleton; TAS:BHF-UCL.
 GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
 GO:0030865; P:cortical cytoskeleton organization; TAS:BHF-UCL.
 GO:0007016; P:cytoskeletal anchoring at plasma membrane; TAS:BHF-UCL.
 GO:0043217; P:myelin maintenance; IMP:BHF-UCL.
 GO:0048812; P:neuron projection morphogenesis; IMP:BHF-UCL.
 GO:0030913; P:paranodal junction assembly; IMP:BHF-UCL.
 GO:0071205; P:protein localization to juxtaparanode region of axon; IMP:BHF-UCL.
 GO:0002175; P:protein localization to paranode region of axon; IMP:BHF-UCL.
 GO:0072659; P:protein localization to plasma membrane; IMP:BHF-UCL.
 GO:0008360; P:regulation of cell shape; IMP:BHF-UCL. 

Interpro

 IPR008379; Band_4.1_C.
 IPR019749; Band_41_domain.
 IPR019750; Band_41_fam.
 IPR021187; Band_41_protein.
 IPR000798; Ez/rad/moesin_like.
 IPR014847; FERM-adjacent.
 IPR014352; FERM/acyl-CoA-bd_prot_3-hlx.
 IPR019748; FERM_central.
 IPR019747; FERM_CS.
 IPR000299; FERM_domain.
 IPR018979; FERM_N.
 IPR018980; FERM_PH-like_C.
 IPR011993; PH_like_dom.
 IPR007477; SAB_dom. 

Pfam

 PF05902; 4_1_CTD
 PF08736; FA
 PF09380; FERM_C
 PF00373; FERM_M
 PF09379; FERM_N
 PF04382; SAB 

SMART

 SM00295; B41 

PROSITE

 PS00660; FERM_1
 PS00661; FERM_2
 PS50057; FERM_3 

PRINTS

 PR00935; BAND41.
 PR00661; ERMFAMILY.