CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015600
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Transmembrane and TPR repeat-containing protein 3 
Protein Synonyms/Alias
 Protein SMILE 
Gene Name
 TMTC3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
460GHALENEKNFERALKubiquitination[1, 2]
738RYYPDHIKGLILKGDubiquitination[1, 2]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 REPEAT 412 445 TPR 1.
 REPEAT 446 479 TPR 2.
 REPEAT 481 513 TPR 3.
 REPEAT 528 562 TPR 4.
 REPEAT 563 596 TPR 5.
 REPEAT 597 631 TPR 6.
 REPEAT 669 702 TPR 7.
 REPEAT 704 736 TPR 8.
 REPEAT 737 771 TPR 9.
 REPEAT 773 805 TPR 10.
 MOD_RES 503 503 Phosphotyrosine.
 CARBOHYD 117 117 N-linked (GlcNAc...) (Potential).
 CARBOHYD 494 494 N-linked (GlcNAc...) (Potential).  
Keyword
 Alternative splicing; Complete proteome; Glycoprotein; Membrane; Phosphoprotein; Reference proteome; Repeat; TPR repeat; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 915 AA 
Protein Sequence
MANINLKEIT LIVGVVTACY WNSLFCGFVF DDVSAILDNK DLHPSTPLKT LFQNDFWGTP 60
MSEERSHKSY RPLTVLTFRL NYLLSELKPM SYHLLNMIFH AVVSVIFLKV CKLFLDNKSS 120
VIASLLFAVH PIHTEAVTGV VGRAELLSSI FFLAAFLSYT RSKGPDNSII WTPIALTVFL 180
VAVATLCKEQ GITVVGICCV YEVFIAQGYT LPLLCTTAGQ FLRGKGSIPF SMLQTLVKLI 240
VLMFSTLLLV VIRVQVIQSQ LPVFTRFDNP AAVSPTPTRQ LTFNYLLPVN AWLLLNPSEL 300
CCDWTMGTIP LIESLLDIRN LATFTFFCFL GMLGVFSIRY SGDSSKTVLM ALCLMALPFI 360
PASNLFFPVG FVVAERVLYV PSMGFCILVA HGWQKISTKS VFKKLSWICL SMVILTHSLK 420
TFHRNWDWES EYTLFMSALK VNKNNAKLWN NVGHALENEK NFERALKYFL QATHVQPDDI 480
GAHMNVGRTY KNLNRTKEAE ESYMMAKSLM PQIIPGKKYA ARIAPNHLNV YINLANLIRA 540
NESRLEEADQ LYRQAISMRP DFKQAYISRG ELLLKMNKPL KAKEAYLKAL ELDRNNADLW 600
YNLAIVHIEL KEPNEALKKN FNRALELNPK HKLALFNSAI VMQESGEVKL RPEARKRLLS 660
YINEEPLDAN GYFNLGMLAM DDKKDNEAEI WMKKAIKLQA DFRSALFNLA LLYSQTAKEL 720
KALPILEELL RYYPDHIKGL ILKGDILMNQ KKDILGAKKC FERILEMDPS NVQGKHNLCV 780
VYFEEKDLLK AERCLLETLA LAPHEEYIQR HLNIVRDKIS SSSFIEPIFP TSKISSVEGK 840
KIPTESVKEI RGESRQTQIV KTSDNKSQSK SNKQLGKNGD EETPHKTTKD IKEIEKKRVA 900
ALKRLEEIER ILNGE 915 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0060447; P:bud outgrowth involved in lung branching; IEA:Compara.
 GO:0048286; P:lung alveolus development; IEA:Compara.
 GO:0048747; P:muscle fiber development; IEA:Compara.
 GO:0009791; P:post-embryonic development; IEA:Compara.
 GO:0010468; P:regulation of gene expression; IEA:Compara. 
Interpro
 IPR013618; DUF1736.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR013105; TPR_2.
 IPR019734; TPR_repeat. 
Pfam
 PF08409; DUF1736
 PF07719; TPR_2
 PF13174; TPR_6
 PF13181; TPR_8 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS