UniProt Accession

 STX12_MOUSE; Q9ER00; Q3UIV9; Q921T9 

Genbank Protein ID

 AB019211; AK077678; AK078948; AK146544; AK146735; AK167087; BC010669 

Genbank Nucleotide ID

 BAB20282.1; BAC36951.1; BAC37473.1; BAE27249.1; BAE27397.1; BAE39244.1; AAH10669.1 

Protein Name

 Syntaxin-12 

Protein Synonyms/Alias

  

Gene Name

 Stx12 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	SQATAQIKNLMSQLG	ubiquitination	[1]
53	LMSQLGTKQDSSKLQ	ubiquitination	[1]
58	GTKQDSSKLQENLQQ	ubiquitination	[1]
82	KETNELLKELGSLPL	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). 

Sequence Annotation

 DOMAIN 178 240 t-SNARE coiled-coil homology.
 MOD_RES 139 139 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 218 218 Phosphoserine.  

Keyword

 Coiled coil; Complete proteome; Endosome; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transmembrane; Transmembrane helix; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0031083; C:BLOC-1 complex; IEA:Compara.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IEA:Compara.
 GO:0045335; C:phagocytic vesicle; IEA:Compara.
 GO:0031201; C:SNARE complex; ISS:UniProtKB.
 GO:0005484; F:SNAP receptor activity; IBA:RefGenome.
 GO:0000149; F:SNARE binding; IBA:RefGenome.
 GO:0033344; P:cholesterol efflux; IEA:Compara.
 GO:0006886; P:intracellular protein transport; IBA:RefGenome.
 GO:0050821; P:protein stabilization; IEA:Compara.
 GO:0016079; P:synaptic vesicle exocytosis; IBA:RefGenome. 

Interpro

 IPR006012; Syntaxin/epimorphin_CS.
 IPR006011; Syntaxin_N.
 IPR010989; t-SNARE.
 IPR000727; T_SNARE_dom. 

Pfam

 PF05739; SNARE
 PF00804; Syntaxin 

SMART

 SM00503; SynN
 SM00397; t_SNARE 

PROSITE

 PS00914; SYNTAXIN
 PS50192; T_SNARE 

PRINTS