CPLM-012189

Genbank Nucleotide ID

Activin receptor type-2B

Protein Synonyms/Alias

Activin receptor type IIB; ACTR-IIB

Homo sapiens (Human)

Position	Peptide	Type	References
224	KIFPLQDKQSWQSER	ubiquitination	[1]

[1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]

Functional Description

Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.

DOMAIN 190 480 Protein kinase.
NP_BIND 196 204 ATP (By similarity).
ACT_SITE 321 321 Proton acceptor (By similarity).
BINDING 217 217 ATP (By similarity).
CARBOHYD 42 42 N-linked (GlcNAc...).
CARBOHYD 65 65 N-linked (GlcNAc...).
DISULFID 29 59
DISULFID 49 77
DISULFID 84 103
DISULFID 90 102
DISULFID 104 109

3D-structure; Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Glycoprotein; Heterotaxy; Kinase; Magnesium; Manganese; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Serine/threonine-protein kinase; Signal; Transferase; Transmembrane; Transmembrane helix.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0009986; C:cell surface; IDA:UniProtKB.
GO:0005737; C:cytoplasm; IDA:HGNC.
GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0017002; F:activin-activated receptor activity; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0004674; F:protein serine/threonine kinase activity; IMP:HGNC.
GO:0004712; F:protein serine/threonine/tyrosine kinase activity; IEA:Compara.
GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
GO:0005024; F:transforming growth factor beta-activated receptor activity; IEA:InterPro.
GO:0032147; P:activation of protein kinase activity; IEA:Compara.
GO:0009952; P:anterior/posterior pattern specification; IMP:HGNC.
GO:0060840; P:artery development; ISS:BHF-UCL.
GO:0001974; P:blood vessel remodeling; ISS:BHF-UCL.
GO:0030509; P:BMP signaling pathway; IDA:BHF-UCL.
GO:0007368; P:determination of left/right symmetry; IEA:Compara.
GO:0048617; P:embryonic foregut morphogenesis; IEA:Compara.
GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
GO:0007507; P:heart development; IEA:Compara.
GO:0030073; P:insulin secretion; IEA:Compara.
GO:0001822; P:kidney development; IEA:Compara.
GO:0030324; P:lung development; IEA:Compara.
GO:0001946; P:lymphangiogenesis; ISS:BHF-UCL.
GO:0060836; P:lymphatic endothelial cell differentiation; ISS:BHF-UCL.
GO:0007498; P:mesoderm development; IEA:Compara.
GO:0042475; P:odontogenesis of dentin-containing tooth; IEA:Compara.
GO:0035265; P:organ growth; IEA:Compara.
GO:0060021; P:palate development; IEA:Compara.
GO:0031016; P:pancreas development; IEA:Compara.
GO:0032927; P:positive regulation of activin receptor signaling pathway; IDA:HGNC.
GO:0030501; P:positive regulation of bone mineralization; IMP:BHF-UCL.
GO:0045669; P:positive regulation of osteoblast differentiation; IMP:BHF-UCL.
GO:0009791; P:post-embryonic development; IEA:Compara.
GO:0009749; P:response to glucose stimulus; IEA:Compara.
GO:0061298; P:retina vasculature development in camera-type eye; ISS:BHF-UCL.
GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
GO:0048705; P:skeletal system morphogenesis; IEA:Compara.
GO:0060841; P:venous blood vessel development; ISS:BHF-UCL.

IPR000333; Activin_II/TGFBeta-II_recpt.
IPR015768; Activin_II_recpt.
IPR000472; Activin_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.

PF01064; Activin_recp
PF00069; Pkinase

PS00107; PROTEIN_KINASE_ATP
PS50011; PROTEIN_KINASE_DOM
PS00108; PROTEIN_KINASE_ST