UniProt Accession

 NQO2_MOUSE; Q9JI75 

Genbank Protein ID

 AF252260; AF254081; AF254076; AF254077; AF254078; AF254079; AF254080; AK010842; BC027629 

Genbank Nucleotide ID

 AAF97785.1; AAF97789.1; AAF97789.1; AAF97789.1; AAF97789.1; AAF97789.1; AAF97789.1; BAB27217.1; AAH27629.1 

Protein Name

 Ribosyldihydronicotinamide dehydrogenase [quinone] 

Protein Synonyms/Alias

 NRH dehydrogenase [quinone] 2; NRH:quinone oxidoreductase 2; Quinone reductase 2; QR2 

Gene Name

 Nqo2 

Gene Synonyms/Alias

 Nmor2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
16	VYAHQEPKSFNGSLK	ubiquitination	[1]
23	KSFNGSLKKVAVEEL	acetylation	[2]
23	KSFNGSLKKVAVEEL	ubiquitination	[1]
77	IETHEAYKKKALTSD	ubiquitination	[1]
79	THEAYKKKALTSDIF	ubiquitination	[1]
139	FYDSGFLKGKLALLS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654] 

Functional Description

 The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. 

Sequence Annotation

 NP_BIND 18 21 FAD (By similarity).
 NP_BIND 104 107 FAD (By similarity).
 NP_BIND 148 151 FAD (By similarity).
 REGION 127 129 Substrate binding (By similarity).
 METAL 174 174 Zinc (By similarity).
 METAL 178 178 Zinc (By similarity).
 METAL 223 223 Zinc (By similarity).
 BINDING 12 12 FAD (By similarity).
 BINDING 156 156 FAD (By similarity).
 BINDING 194 194 FAD (By similarity).
 BINDING 201 201 FAD (By similarity).
 MOD_RES 197 197 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; FAD; Flavoprotein; Metal-binding; Oxidoreductase; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 231 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0001512; F:dihydronicotinamide riboside quinone reductase activity; IEA:EC.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0007613; P:memory; IEA:Compara. 

Interpro

 IPR003680; Flavodoxin_fold. 

Pfam

 PF02525; Flavodoxin_2 

SMART

  

PROSITE

  

PRINTS