UniProt Accession

 GPS2_HUMAN; Q13227; Q6FHM8 

Genbank Protein ID

 U28963; BT006998; CR541723; CR541750; AL122080; AL157493; BC013652; BC103901; BC103903; BC107738 

Genbank Nucleotide ID

 AAB60432.1; AAP35644.1; CAG46524.1; CAG46550.1; CAB59255.1; CAB75677.2; AAH13652.1; AAI03902.1; AAI03904.1; AAI07739.1 

Protein Name

 G protein pathway suppressor 2 

Protein Synonyms/Alias

 GPS-2 

Gene Name

 GPS2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	RMSLEETKEQILKLE	ubiquitination	[1, 2]
71	ETKEQILKLEEKLLA	ubiquitination	[2]
75	QILKLEEKLLALQEE	ubiquitination	[2]
83	LLALQEEKHQLFLQL	ubiquitination	[2]
92	QLFLQLKKVLHEEEK	ubiquitination	[2]
151	LMAADRAKQMFGPQV	ubiquitination	[2]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
 GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.
 GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.
 GO:0007049; P:cell cycle; TAS:ProtInc.
 GO:0000188; P:inactivation of MAPK activity; TAS:ProtInc.
 GO:0007254; P:JNK cascade; TAS:ProtInc.
 GO:0046329; P:negative regulation of JNK cascade; IDA:UniProtKB.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB. 

Interpro

 IPR026094; GPS2. 

Pfam

  

SMART

  

PROSITE

  

PRINTS