CPLM-009071

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-009071

UniProt Accession

DHB7_HUMAN; P56937; Q5T246; Q7Z4V9; Q8WWS2; Q9UF00

Genbank Protein ID

AF098786; AF162767; AF162759; AF162760; AF162761; AF162762; AF162763; AF162764; AF162765; AF162766; AJ249179; AJ250550; AJ250551; AJ250552; AJ250553; AJ250554; AJ250555; AJ250556; AJ250557; AJ250558; AF145023; AY358962; AK290741; BT007075; AL392003; AL445197; AL445197; AL392003; CH471067; BC007068; BC065246

Genbank Nucleotide ID

AAF09266.2; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; AAF14537.1; CAC20418.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; CAC88111.1; AAP97275.1; AAQ89321.1; BAF83430.1; AAP35738.1; CAI13457.1; CAI13457.1; CAI15947.1; CAI15947.1; EAW90716.1; AAH07068.1; AAH65246.1

Protein Name

3-keto-steroid reductase

Protein Synonyms/Alias

17-beta-hydroxysteroid dehydrogenase 7; 17-beta-HSD 7; Estradiol 17-beta-dehydrogenase 7

Gene Name

HSD17B7

Gene Synonyms/Alias

UNQ2563/PRO6243

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
293	RNYIMTQKMDLDEDT	ubiquitination	[1]
303	LDEDTAEKFYQKLLE	ubiquitination	[1]
307	TAEKFYQKLLELEKH	ubiquitination	[1]
321	HIRVTIQKTDNQARL	ubiquitination	[1]

Reference

[1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]

Functional Description

Responsible for the reduction of the keto group on the C-3 of sterols.

Sequence Annotation

NP_BIND 8 15 NAD (Potential).
ACT_SITE 193 193 Proton acceptor (By similarity).
BINDING 171 171 Substrate (By similarity).
CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
CARBOHYD 229 229 N-linked (GlcNAc...) (Potential).

Keyword

Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Lipid biosynthesis; Lipid metabolism; Membrane; NAD; NADP; Oxidoreductase; Reference proteome; Steroid biosynthesis; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

341 AA

Protein Sequence

MRKVVLITGA SSGIGLALCK RLLAEDDELH LCLACRNMSK AEAVCAALLA SHPTAEVTIV 60
QVDVSNLQSV FRASKELKQR FQRLDCIYLN AGIMPNPQLN IKALFFGLFS RAEGLLTQGD 120
KITADGLQEV FETNVFGHFI LIRELEPLLC HSDNPSQLIW TSSRSARKSN FSLEDFQHSK 180
GKEPYSSSKY ATDLLSVALN RNFNQQGLYS NVACPGTALT NLTYGILPPF IWTLLMPAIL 240
LLRFFANAFT LTPYNGTEAL VWLFHQKPES LNPLIKYLSA TTGFGRNYIM TQKMDLDEDT 300
AEKFYQKLLE LEKHIRVTIQ KTDNQARLSG SCL 333

Gene Ontology

GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0000253; F:3-keto sterol reductase activity; IEA:EC.
GO:0004303; F:estradiol 17-beta-dehydrogenase activity; TAS:ProtInc.
GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.
GO:0006703; P:estrogen biosynthetic process; IEA:UniProtKB-UniPathway.

Interpro

IPR002198; DH_sc/Rdtase_SDR.
IPR002347; Glc/ribitol_DH.
IPR016040; NAD(P)-bd_dom.

Pfam

PF00106; adh_short

SMART

PROSITE

PS00061; ADH_SHORT

PRINTS

PR00081; GDHRDH.