UniProt Accession

 DPH3_MOUSE; Q8K0W9 

Genbank Protein ID

 AK048097; AK011448; BC029910; BC039954 

Genbank Nucleotide ID

 BAC33240.1; BAC25335.1; AAH29910.1; AAH39954.1 

Protein Name

 DPH3 homolog 

Protein Synonyms/Alias

 CSL-type zinc finger-containing protein 2; DelGEF-interacting protein 1; DelGIP1 

Gene Name

 Dph3 

Gene Synonyms/Alias

 Desr1; Zcsl2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
61	IIKVIYDKDQFMCGE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (By similarity). 

Sequence Annotation

 ZN_FING 4 60 DPH-type.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 82 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0050709; P:negative regulation of protein secretion; ISS:UniProtKB.
 GO:0017183; P:peptidyl-diphthamide biosynthetic process from peptidyl-histidine; ISS:UniProtKB.
 GO:0051099; P:positive regulation of binding; ISS:UniProtKB. 

Interpro

 IPR007872; Znf_DHP. 

Pfam

 PF05207; zf-CSL 

SMART

  

PROSITE

 PS51074; ZF_DPH 

PRINTS