UniProt Accession

 LIPL_MOUSE; P11152; Q05956; Q542L4; Q9D3M9; Q9DCM8 

Genbank Protein ID

 M60847; M60838; M60839; M60840; M60842; M60843; M60844; M60845; M60846; AK002645; AK017272; AK045064; AK086023; AK150355; AK150375; AK150457; AK150488; AK150505; AK150593; AK150672; AK151006; AK151093; AK151105; AK151369; AK151434; AK151521; AK151540; AK151563; AK151630; AK151679; AK151727; AK151772; AK151801; AK151828; AK151866; AK151870; AK151872; AK151893; AK152014; AK152035; AK152049; AK152053; AK152079; AK152350; AK152657; AK153148; AK153242; AK153425; AK159268; AK170486; BC003305; M65258; J03302; M63335 

Genbank Nucleotide ID

 AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; AAA39441.1; BAB22256.1; BAC32204.1; BAC39594.1; BAE29491.1; BAE29507.1; BAE29577.1; BAE29604.1; BAE29618.1; BAE29686.1; BAE29754.1; BAE30029.1; BAE30105.1; BAE30115.1; BAE30343.1; BAE30397.1; BAE30470.1; BAE30486.1; BAE30505.1; BAE30564.1; BAE30604.1; BAE30645.1; BAE30678.1; BAE30701.1; BAE30723.1; BAE30754.1; BAE30758.1; BAE30760.1; BAE30777.1; BAE30876.1; BAE30894.1; BAE30905.1; BAE30909.1; BAE30930.1; BAE31144.1; BAE31394.1; BAE31758.1; BAE31834.1; BAE31984.1; BAE34947.1; BAE41828.1; AAH03305.1; AAA39442.1; AAA39440.1; AAC04464.1 

Protein Name

 Lipoprotein lipase 

Protein Synonyms/Alias

 LPL 

Gene Name

 Lpl 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
40	DFSDIESKFALRTPE	ubiquitination	[1]
129	PVSAGYTKLVGNDVA	ubiquitination	[1]
265	GDVDQLVKCSHERSI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity). 

Sequence Annotation

 DOMAIN 341 464 PLAT.
 REGION 346 441 Heparin-binding (By similarity).
 ACT_SITE 159 159 Nucleophile (By similarity).
 ACT_SITE 183 183 Charge relay system (By similarity).
 ACT_SITE 268 268 Charge relay system (By similarity).
 MOD_RES 121 121 Nitrated tyrosine (By similarity).
 MOD_RES 191 191 Nitrated tyrosine (By similarity).
 MOD_RES 343 343 Nitrated tyrosine (By similarity).
 CARBOHYD 70 70 N-linked (GlcNAc...) (Potential).
 CARBOHYD 386 386 N-linked (GlcNAc...) (Potential).
 DISULFID 54 67 By similarity.
 DISULFID 243 266 By similarity.
 DISULFID 291 310 By similarity.
 DISULFID 302 305 By similarity.
 DISULFID 445 465 By similarity.  

Keyword

 Cell membrane; Chylomicron; Complete proteome; Disulfide bond; Glycoprotein; GPI-anchor; Heparin-binding; Hydrolase; Lipid degradation; Lipid metabolism; Lipoprotein; Membrane; Nitration; Reference proteome; Secreted; Signal; VLDL. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 474 AA 

Protein Sequence

Gene Ontology

 GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0042627; C:chylomicron; IEA:UniProtKB-KW.
 GO:0031012; C:extracellular matrix; IEA:Compara.
 GO:0005615; C:extracellular space; IDA:BHF-UCL.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0004465; F:lipoprotein lipase activity; IDA:MGI.
 GO:0017129; F:triglyceride binding; IEA:Compara.
 GO:0004806; F:triglyceride lipase activity; IDA:BHF-UCL.
 GO:0010886; P:positive regulation of cholesterol storage; IEA:Compara.
 GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IGI:BHF-UCL.
 GO:0010890; P:positive regulation of sequestering of triglyceride; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0019432; P:triglyceride biosynthetic process; IEA:Compara.
 GO:0019433; P:triglyceride catabolic process; IDA:BHF-UCL.
 GO:0070328; P:triglyceride homeostasis; IEA:Compara. 

Interpro

 IPR000734; Lipase.
 IPR008976; Lipase_LipOase.
 IPR013818; Lipase_N.
 IPR002330; Lipo_Lipase.
 IPR001024; LipOase_LH2.
 IPR016272; Lipoprotein_lipase_LIPH. 

Pfam

 PF00151; Lipase
 PF01477; PLAT 

SMART

 SM00308; LH2 

PROSITE

 PS00120; LIPASE_SER
 PS50095; PLAT 

PRINTS

 PR00822; LIPOLIPASE.
 PR00821; TAGLIPASE.