UniProt Accession

 SRP14_MOUSE; P16254; Q3TIK2 

Genbank Protein ID

 M29264; AK019310; AK156845; AK167821; AK168144; BC021537 

Genbank Nucleotide ID

 AAA40136.1; BAB31658.1; BAE33873.1; BAE39844.1; BAE40110.1; AAH21537.1 

Protein Name

 Signal recognition particle 14 kDa protein 

Protein Synonyms/Alias

 SRP14; Signal recognition particle 14 kDa protein, N-terminally processed 

Gene Name

 Srp14 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
43	RTKPIPRKSSVEGLE	ubiquitination	[1]
74	ISTVVSSKEVNKFQM	ubiquitination	[1]
78	VSSKEVNKFQMAYSN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding. 

Sequence Annotation

 MOD_RES 45 45 Phosphoserine.  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 110 AA 

Protein Sequence

Gene Ontology

 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IEA:UniProtKB-KW.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0030942; F:endoplasmic reticulum signal peptide binding; IEA:InterPro.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IEA:InterPro. 

Interpro

 IPR003210; Signal_recog_particle_SRP14.
 IPR009018; Signal_recog_particle_SRP9/14. 

Pfam

 PF02290; SRP14 

SMART

  

PROSITE

  

PRINTS