CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Trehalose synthase complex regulatory subunit TPS3 
Protein Synonyms/Alias
 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 115 kDa subunit 
Gene Name
 TPS3 
Gene Synonyms/Alias
 YMR261C; YM8156.03C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
389ITFKGAYKNYAKQILubiquitination[1]
878VAKIFDEKVERLPGSubiquitination[1]
1010EPLFKLVKQEVEKNNacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Regulatory subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6- phosphate and UDP-glucose in a two step process. May stabilize the trehalose synthase complex. 
Sequence Annotation
 REGION 287 778 Glycosyltransferase.
 MOD_RES 148 148 Phosphoserine.
 MOD_RES 150 150 Phosphoserine.
 MOD_RES 181 181 Phosphoserine.
 MOD_RES 265 265 Phosphothreonine.
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 273 273 Phosphoserine.
 MOD_RES 960 960 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1054 AA 
Protein Sequence
MTIIVASLFL PYTPQFEADV TNSDTAKLVE SSMIKVDCNN QELSNNKQER SSSVTSASSH 60
YIGLPQEAQI NGEPLQRANV GSPATGVNYH NEMEMLSSEQ FLEELTANAT HAANSGIPPA 120
NNPVSSGSTA QRPSVEEFFS APSARVCSPS QEASASSISA SRSSAHHNDL SSSLMKNPNL 180
SFDSHPPRVR SSSKSAVITP VSKSVPDVDP AVVDVAKVRE EFQQQASLPS MKRVSGSTAG 240
DSSIASSSSN LRYSQQFQDN FIEDTDSEDD IDSDLETDAT KKYNVPKFGG YSNNAKLRAS 300
LMRNSYELFK HLPWTIVDSD KGNGSLKNAV NIAVAEKTVK EPVSWVGTMG IPTDELPHEV 360
CHKISKKLEQ DFSSFPVVTD DITFKGAYKN YAKQILWPTL HYQIPDNPNS KAFEDHSWDY 420
YQKVNQKFSD RIVSVYKPGD TIWIHDYHLM LVPQMVREKL PKAKIGFFLH VSFPSSEVFR 480
CLANRERILE GIIGANFVGF QTKEYKRHFL QTCNRLLAAD VSNDEVKYHC NIVSVMYAPI 540
GIDYYHLTSQ LRNGSVLEWR QLIKERWRNK KLIVCRDQFD RIRGLQKKML AYERFLIENP 600
EYIEKVVLIQ ICIGKSSDPE YERQIMVVVD RINSLSSNIS ISQPVVFLHQ DLDFAQYLAL 660
NCEADVFLVD ALREGMNLTC HEFIVSSFEK NAPLLLSEFT GSSSVLKEGA ILINPWDINH 720
VAQSIKRSLE MSPEEKRRRW KKLFKSVIEH DSDNWITKCF EYINNAWESN QETSTVFNLA 780
PEKFCADYKA SKKHLFIFKI SEPPTSRMLS LLSELSSNNI VYVLSSFTKN TFESLYNGVL 840
NIGLIAENGA YVRVNGSWYN IVEELDWMKE VAKIFDEKVE RLPGSYYKIA DSMIRFHTEN 900
ADDQDRVPTV IGEAITHINT LFDDRDIHAY VHKDIVFVQQ TGLALAAAEF LMKFYNSGVS 960
PTDNSRISLS RTSSSMSVGN NKKHFQNQVD FVCVSGSTSP IIEPLFKLVK QEVEKNNLKF 1020
GYTILYGSSR STYAKEHING VNELFTILHD LTAA 1054 
Gene Ontology
 GO:0005946; C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming); IGI:SGD.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0030234; F:enzyme regulator activity; IMP:SGD.
 GO:0005992; P:trehalose biosynthetic process; IGI:SGD. 
Interpro
 IPR001830; Glyco_trans_20.
 IPR023214; HAD-like_dom.
 IPR003337; Trehalose_PPase. 
Pfam
 PF00982; Glyco_transf_20
 PF02358; Trehalose_PPase 
SMART
  
PROSITE
  
PRINTS