| Tag | Content |
|---|
| CPLM ID | CPLM-015522 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Kelch-like protein 9 |
Protein Synonyms/Alias | |
Gene Name | Klhl9 |
Gene Synonyms/Alias | Kiaa1354 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 20 | SAHLQPCKSGTTRFF | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). |
Sequence Annotation | DOMAIN 50 119 BTB.
DOMAIN 154 255 BACK.
REPEAT 299 347 Kelch 1.
REPEAT 348 399 Kelch 2.
REPEAT 400 446 Kelch 3.
REPEAT 448 493 Kelch 4.
REPEAT 495 545 Kelch 5.
REPEAT 546 594 Kelch 6. |
Keyword | Cell cycle; Cell division; Complete proteome; Kelch repeat; Mitosis; Reference proteome; Repeat; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 617 AA |
Protein Sequence | MKVSLGNGDM GVSAHLQPCK SGTTRFFTSN THSSVVLQGF DQLRIEGLLC DVTLVPGDGE 60
EIFPVHRAMM ASASDYFKAM FTGGMKEKDL MCIKLHGVNK VGLKKIIDFI YTAKLSLNMD 120
NLQDTLEAAS FLQILPVLDF CKVFLISGVS LDNCVEVGRI ANTYNLIEVD KYVNNFILKN 180
FPALLNTGEF LKLPFERLAF VLSSNSLKHC SELELFKAAC RWLRLEDPRM DYAAKLMKNI 240
RFPLMTPQDL INYVQTVDFM RTDNTCVNLL LEASNYQMMP YMQPVMQSDR TAIRSDSTHL 300
VTLGGVLRQQ LVVSKELRMY DERAQEWKSL APMDAPRYQH GIAVIGNFLY VVGGQSNYDT 360
KGKTAVDTVF RFDPRYNKWM QVASLNEKRT FFHLSALKGH LYAVGGRSAA GELATVECYN 420
PRMNEWSYVA KMSEPHYGHA GTVYGGLMYI SGGITHDTFQ NELMCFDPDT DKWTQKAPMT 480
TVRGLHCMCT VGDKLYVIGG NHFRGTSDYD DVLSCEYYSP TLDQWTPIAA MLRGQSDVGV 540
AVFENKIYVV GGYSWNNRCM VEIVQKYDPE KDEWHKVFDL PESLGGIRAC TLTVFPPEEN 600
PGSPSRESPL SAPSDHS 617 |
Gene Ontology | GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB. GO:0030496; C:midbody; ISS:UniProtKB. GO:0004842; F:ubiquitin-protein ligase activity; IEA:Compara. GO:0000910; P:cytokinesis; ISS:UniProtKB. GO:0007067; P:mitosis; IEA:UniProtKB-KW. GO:0016567; P:protein ubiquitination; ISS:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |