| Tag | Content |
|---|
| CPLM ID | CPLM-021469 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Dedicator of cytokinesis protein 5 |
Protein Synonyms/Alias | |
Gene Name | DOCK5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 818 | KIKGAALKYLPSIIN | acetylation | [1] |
|
Reference | [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions. Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M. Science. 2009 Aug 14;325(5942):834-40. [ PMID: 19608861] |
Functional Description | Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. |
Sequence Annotation | DOMAIN 8 69 SH3.
DOMAIN 443 627 DHR-1.
DOMAIN 1231 1642 DHR-2.
MOD_RES 365 365 Phosphoserine.
MOD_RES 818 818 N6-acetyllysine.
MOD_RES 1766 1766 Phosphoserine.
MOD_RES 1789 1789 Phosphoserine.
MOD_RES 1794 1794 Phosphothreonine.
MOD_RES 1814 1814 Phosphothreonine.
MOD_RES 1834 1834 Phosphoserine.
MOD_RES 1869 1869 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Guanine-nucleotide releasing factor; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1870 AA |
Protein Sequence | MARWIPTKRQ KYGVAIYNYN ASQDVELSLQ IGDTVHILEM YEGWYRGYTL QNKSKKGIFP 60
ETYIHLKEAT VEDLGQHETV IPGELPLVQE LTSTLREWAV IWRKLYVNNK LTLFRQLQQM 120
TYSLIEWRSQ ILSGTLPKDE LAELKKKVTA KIDHGNRMLG LDLVVRDDNG NILDPDETST 180
IALFKAHEVA SKRIEEKIQE EKSILQNLDL RGQSIFSTIH TYGLYVNFKN FVCNIGEDAE 240
LFMALYDPDQ STFISENYLI RWGSNGMPKE IEKLNNLQAV FTDLSSMDLI RPRVSLVCQI 300
VRVGHMELKE GKKHTCGLRR PFGVAVMDIT DIIHGKVDDE EKQHFIPFQQ IAMETYIRQR 360
QLIMSPLITS HVIGENEPLT SVLNKVIAAK EVNHKGQGLW VSLKLLPGDL TQVQKNFSHL 420
VDRSTAIARK MGFPEIILPG DVRNDIYVTL IHGEFDKGKK KTPKNVEVTM SVHDEEGKLL 480
EKAIHPGAGY EGISEYKSVV YYQVKQPCWY ETVKVSIAIE EVTRCHIRFT FRHRSSQETR 540
DKSERAFGVA FVKLMNPDGT TLQDGRHDLV VYKGDNKKME DAKFYLTLPG TKMEMEEKEL 600
QASKNLVTFT PSKDSTKDSF QIATLICSTK LTQNVDLLGL LNWRSNSQNI KHNLKKLMEV 660
DGGEIVKFLQ DTLDALFNIM MEMSDSETYD FLVFDALVFI ISLIGDIKFQ HFNPVLETYI 720
YKHFSATLAY VKLSKVLNFY VANADDSSKT ELLFAALKAL KYLFRFIIQS RVLYLRFYGQ 780
SKDGDEFNNS IRQLFLAFNM LMDRPLEEAV KIKGAALKYL PSIINDVKLV FDPVELSVLF 840
CKFIQSIPDN QLVRQKLNCM TKIVESTLFR QSECREVLLP LLTDQLSGQL DDNSNKPDHE 900
ASSQLLSNIL EVLDRKDVGA TAVHIQLIME RLLRRINRTV IGMNRQSPHI GSFVACMIAL 960
LQQMDDSHYS HYISTFKTRQ DIIDFLMETF IMFKDLIGKN VYAKDWMVMN MTQNRVFLRA 1020
INQFAEVLTR FFMDQASFEL QLWNNYFHLA VAFLTHESLQ LETFSQAKRN KIVKKYGDMR 1080
KEIGFRIRDM WYNLGPHKIK FIPSMVGPIL EVTLTPEVEL RKATIPIFFD MMQCEFNFSG 1140
NGNFHMFENE LITKLDQEVE GGRGDEQYKV LLEKLLLEHC RKHKYLSSSG EVFALLVSSL 1200
LENLLDYRTI IMQDESKENR MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HRDCENYTEA 1260
AYTLLLHAEL LQWSDKPCVP HLLQKDSYYV YTQQELKEKL YQEIISYFDK GKMWEKAIKL 1320
SKELAETYES KVFDYEGLGN LLKKRASFYE NIIKAMRPQP EYFAVGYYGQ GFPSFLRNKI 1380
FIYRGKEYER REDFSLRLLT QFPNAEKMTS TTPPGEDIKS SPKQYMQCFT VKPVMSLPPS 1440
YKDKPVPEQI LNYYRANEVQ QFRYSRPFRK GEKDPDNEFA TMWIERTTYT TAYTFPGILK 1500
WFEVKQISTE EISPLENAIE TMELTNERIS NCVQQHAWDR SLSVHPLSML LSGIVDPAVM 1560
GGFSNYEKAF FTEKYLQEHP EDQEKVELLK RLIALQMPLL TEGIRIHGEK LTEQLKPLHE 1620
RLSSCFRELK EKVEKHYGVI TLPPNLTERK QSRTGSIVLP YIMSSTLRRL SITSVTSSVV 1680
STSSNSSDNA PSRPGSDGSI LEPLLERRAS SGARVEDLSL REENSENRIS KFKRKDWSLS 1740
KSQVIAEKAP EPDLMSPTRK AQRPKSLQLM DNRLSPFHGS SPPQSTPLSP PPLTPKATRT 1800
LSSPSLQTDG IAATPVPPPP PPKSKPYEGS QRNSTELAPP LPVRREAKAP PPPPPKARKS 1860
GIPTSEPGSQ 1870 |
Gene Ontology | GO:0005737; C:cytoplasm; ISS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB. GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |